Intense physical activity over longer periods of time can deprive the brain of energy necessary for its function. Taken orally, arginine Pyroglutamate crosses into the brain, since it easily breaches the blood-brain barrier to stimulate energetic processes in the brain and improve cognitive functions. As such, Arginine Pyroglutamate/Lysine is the perfect blend of amino acids that ensures proper nutrition for both the body and the mind. Arginine Pyroglutamate is a substance in which the amino acid arginine is coupled with a Pyroglutamate molecule. Pyroglutamate is a naturally occurring amino acid found in vegetables, fruit, dairy products and meat. There are no side effects. These are amino acids that are normally present in the foodstuffs consumed by people on a daily basis. Of course, any adverse effects depend upon the amount of amino acids taken. If taken in the recommended dosage of one and one-half to two grams of arginine Pyroglutamate and 750 to 1000 milligram of lysine, no side effects should result. Ultimate Nutrition´s Arginine Pyroglutamate/Lysine combines these amino acids in the right amounts ingested over a 24-hour period. It is best taken before bedtime to maximize its beneficial effects.