Quote Originally Posted by Prisoner#22 View Post
Yah you are right, I was over generalizing.

The thiazide diuretcs have effects SIMMILAR to those of the loop duretics. Much like loop diuretics, thiazides increase renal excretion of sodium, chloride, potassium and water. In addition, thiazides elevate plasma levels of uric acid and glucose. The principal difference between the thiazides and the high-ceiling (loop) diuritics is that the maxium diuresis produced by the thiazides is considerably lower than the maximum diuresis produced by the high-ceiling agents. Additionally whereas loop diuretics can be effective even when urine flow is scant, (such as in patients with severe renal impairment)... the loop diuretics are usually effective even with low glomular filtration rates. The thiazides are not.

Mechanisms of action ... basically the thiazides work in the distal convoluted tubule (just past the ascending tubule of the loop) . The promote uring production by blocking reuptake of sodium and chloride... but they also increase renal excretion of potassium.


Basically the difference between a thiazide and a loop, is that the loop is more effective at doing its job.

**that becomes the problem

The way I see it, taking a loop in lower dosages isn't any different than taking a thiazide in higher dossage, other than you can be sure the loop is going to make you pee.

**more is not better.

So yah from a safety stand point, if you don't know what you are doing than taking a thiazide is a safer bet, as its got a built in safety mechanism.

**fine tuning....not pulling hard

That being said, I have give loads of lasix iv push to patients in the hospital. I have had patients who take lasix at 120 mg oral twice a day, every day.

** awful stuff...tried it a few times....it like death warmed over

Bottom line IMO is diuretics are much safer if you know what you are doing than the sodium depletion/ water loading methods.
**couldnt agree more

the other rule of thumb is LESS diuretic is BEST.

**BINGO....best advice yet!!!

The leaner you are though, the less you have to worry anyway about drying out, as there will be no place to hold water anyways.
**BINGO again....most guys who are "holding water" are spelling water incorrectly....it should be F.A.T ;o)

P