CJC-1295 and GHRP-6 Info.

[spiderman7]

Dehydroepiandrosterone (DHEA) modulates GHRH, somatostatin and angiotensin II action at the pituitary level
C Suárez, J Vela, I García-Tornadú and D Becu-Villalobos

Instituto de Biología y Medicina Experimental, CONICET, V, Obligado 2490, Buenos Aires 1428, Argentina

(Requests for offprints should be addressed to D Becu-Villalobos; Email: dbecu@dna.uba.ar)

In view of the present controversy related to the potential beneficial effects of clinical dehydroepiandrosterone (DHEA) treatments, and considering our own previous results that reveal an influence of this steroid in pituitary hyperplasia development in vivo in rats, we decided to evaluate the role of DHEA in prolactin and GH secretion, as well as in second messengers involved, in cultured rat anterior pituitary cells. DHEA (1 x 10–5 to 1 x 10–7 M) did not modify basal GH or prolactin release, and a prolactin inhibitory effect was observed only for androstenediol, a metabolite of DHEA. DHEA partially prevented dopamine (1 x 10–6 M)-induced prolactin inhibition and facilitated the prolactin-releasing effect of 10–8 M Ang II, without modifying the resulting Ca2+i mobilization. Furthermore, DHEA potentiated the GH release and cAMP production induced by 1 x 10–8 M GHRH. Finally, DHEA partially reversed the inhibitory effect of 1 x 10–8 M somatostatin on GH, but not prolactin, release. We conclude that DHEA in vitro, directly or indirectly through conversion into metabolites, is able to modulate the hormonal response of the pituitary to hypothalamic regulators. It can enhance pituitary prolactin release and induce GH secretion. These effects could help explain some of the side effects observed in prolonged DHEA treatments in vivo and should be taken into account when considering its use in human clinical trials.

[Solo59]

Gym acquaintance of some experience suggested that I'd probably get better results to double the GHRP-6 I've been using rather than simply adding CJC-1295 to my regular dose of GHRP-6.

Of course, there's no experimental evidence on this, but I was wondering if any other peptide users out there might agree (before I order myself another order of the two products). Anyone?

Solo

[spiderman7]

I've been using 150mcg of ghrp-6 every mourning and before bed I use 150 mcg of ghrp-2.
I have not used the cjc as of yet. What I can tell you is the results I'm getting is about the same as 2 iu's of blue tops.

[Solo59]

I've been using 150mcg of ghrp-6 every mourning and before bed I use 150 mcg of ghrp-2.
I have not used the cjc as of yet. What I can tell you is the results I'm getting is about the same as 2 iu's of blue tops.

Thanks Spidey. After further research, it seems clear that either GHRP leads to a quick, tall wavelength pulse of natural GH. What the CJC-1295 (or its equivalents) does is to synergize with GHRP to increase not the height (or intensity) of the wavelength of the pulse but the the breadth (or time) of the wavelength. This means increased natural GH for a much longer period. The "synergy" thing means, apparently, that the overall effect time of one's own natural GH is much more than just the addition of two peptides.

So I'll be getting the GHRP-6 with more CJC-1295. I used my first two "kits" up by mixing the peptides together in one solution. Now I learn that mixing them causes (or may cause) depronation (loss of binding at the molecular level), so I'll be keeping the two peptide solutions separate even when I inject them. Damned, more pinning!

Solo

[mcgirkz]

i read that thread from Dat.. pretty indepth,, to say the least..

so i am thinking of trying CJC-1295 at 100mcg per dose and GHRP-6 at 100mcg per dose. and doses taken 2x a day one PWO and the other before bed, both IM injects.. this would be in addition to test and tren..

any feedback would be appreciated

thanks

[cog]

If you guys sift through those many and long threads,dat has changed his view on the CJC-1295.As Solo noted,the CJC makes the pulses longer,or as dat puts it,leaky.Apparently over time this is no longer effective.He prefers the GRF1-29.

[mcgirkz]

i can remember reading something on a GH bleed? that what you are refering to?

anyhoo.. glad to have your feedback

what sort of protocol are you following cog?

[Solo59]

If you guys sift through those many and long threads,dat has changed his view on the CJC-1295.As Solo noted,the CJC makes the pulses longer,or as dat puts it,leaky.Apparently over time this is no longer effective.He prefers the GRF1-29.

Damned, that would be a lot cheaper than using both of the other two!

Solo

[mcgirkz]

can you guys post some feedback to any progress you have seen using these compounds?

[mcgirkz]

what size pin can be used for doing 3x/day IM shots?