CANADA BODYBUILDING - CANADIAN BODYBUILDING FORUM
Page 1 of 2 12 LastLast
Results 1 to 10 of 15
  1. #1
    Wannabe
    Join Date
    Nov 2011
    Location
    Nova Scotia, Halifax
    Posts
    113
    Rep Power
    3

    Default Do peptides work?

    I try to do as much reading/research as possible before asking a question but I am skeptical of results because with every positive read (muscle gain, fat loss)there are articles about them not working. I have read on here of some people using peptides, has anybody had any success with them if so what type, length of time needed for gains? I guess in short do they work/worth the money? I know the results will not be as good as the real stuff. Should a person who has trained half ass most of his life try them?

  2. #2
    Canadian Bodybuilding Champ
    Join Date
    May 2007
    Location
    british columbia
    Posts
    2,248
    Rep Power
    15

    Default

    here's some of the best info I have come across on the net.

    What types of Growth Hormone Releasing Hormones are there?
    Growth Hormone Releasing Hormones (GHRH) (amplifies the Growth Hormone Releasing Peptides (GHRP) initiated pulse):
    - GRF(1-44) - half-life is less than 5-10 minutes
    - GRF(1-29) Sermorelin - half-life is less than 5-10 minutes
    - Modified GRF(1-29) or CJC-1295 w/o the DAC - Half-life at least 30 minutes
    - CJC-1295 (with DAC) - Half-life measured in days

    Growth Hormone Releasing Hormone (GHRH) pulses can only last less than 30 minutes before your body has used out the potential for a single growth hormone pulse. Since another pulse won't be generated for about 2.5 - 3 hours hormones that last more than 30 minutes up to 3 hours are not any more beneficial.

    The administration of Growth Hormone Releasing Hormone (GHRH) creates a pulse of growth hormone release which will be small if administered during a natural growth hormone trough and higher if administered during a rising natural growth hormone wave.

    What types of Growth Hormone Releasing Peptides are there?
    Growth Hormone Releasing Peptides (GHRP) (Growth hormone pulse initiators):
    - Ipamorelin is potent but the weakest growth hormone releaser. It does not increase cortisol or prolactin at any dose.
    - GHRP-6 is very potent in effecting growth hormone release. It does not effect cortisol or prolactin up to a 100mcg dose, but does so minimally above 100mcg.
    - GHRP-2 is a little bit more potent then GHRP-6. It also has a stronger effect on these hormones at all dosing levels rising to the high normal range for cortisol and prolactin.
    - Hexarelin the strongest is a little more potent then GHRP-2. At all dosing levels it has the strongest impact on cortisol and prolactin with levels in the upper bounds of normalcy.

    Growth Hormone Releasing Peptides (GHRP) can become desensitized with constant usage throughout the day. Ipamorelin and GHRP-6 do not desensitize as long as there are short breaks between doses minimal 2 hours. GHRP-2 does not desensitize in the lower dose ranges without short breaks. At high dose it is unclear, but some desensitization may occur. Hexarelin has been shown to desensitize without regard to dose and even with short breaks between doses. This effect shows up after 14 days of continuous use and may be avoided by either keeping doses low or taking a full day or two off every two weeks.

    Growth Hormone Releasing Peptides (GHRP) are capable of creating a larger pulse of growth hormone on their own than Growth Hormone Releasing Hormone (GHRH) and they do this with much more consistency and predictability without regard to whether a natural wave or trough of growth hormone is currently taking place.

    How much Growth Hormone Releasing Hormone (GHRH) should be used?
    The saturation dose in most studies is defined as 100mcg or 1mcg/kg per growth hormone pulse.

    How long should Growth Hormone Releasing Hormone (GHRH) be used?
    In most studies no adverse side effects were reported with use for 4-8 weeks (per the dosage limits in the above answer) followed by 4 weeks of non-use.

    How much Growth Hormone Releasing Peptides (GHRP) should be used?
    The saturation dose in most studies on Growth Hormone Releasing Peptides (GHRP) is defined as either 100mcg or 1mcg/kg. However that would assume a 100% pure peptide. Note: In general you it is recommended that your dose is rounded up to 150mcg unless the manufacturer advises otherwise.

    This means that 100mcg will saturate the receptors fully, but if you add another 100mcg to that dose only 50% of that portion will be effective. If you add an additional 100mcg to that dose only about 25% will be effective. Perhaps a final 100mcg might add a little something to growth hormone release but that is it.

    If 100mcg is the saturation dose, you could add more (up to 300-400mcg) and get a little more effect. A 500mcg dose will not be more effective than a 400mcg, perhaps not even more effective than 300mcg.

    The additional problems with higher dosages are desensitization and cortisol/prolactin side-effects.

    Ipamorelin and GHRP-6 at the saturation dose of 100mcg does not really increase prolactin & cortisol but may do so slightly at higher doses. This rise is still within the normal range. It can be used at saturation dose (100mcg) three or four times a day without risk of desensitization.

    GHRP-2 is more effective then GHRP-6 at causing growth hormone release but at the saturation dose of a 100mcg or higher may produce a slight to moderate increase in prolactin & cortisol. This rise is still within the normal range although doses of 200 - 400mcg might make it the high end of the normal range. It can be used at saturation dose several times a day will not result in desensitization.

    Hexarelin in general is the most effective at causing an increase in growth hormone release. However it has the highest potential to also increase cortisol & prolactin. This rise will occur even at the 100mcg saturation dose. This rise will reach the higher levels of what is defined as normal. It has been shown to bring about desensitization but in a long-term study the pituitary recovered its sensitivity so that there was not long-term loss of sensitivity at saturation dose. Even at 100mcg three times a day will likely lead to some down regulation within 14 days.

    If desensitization were to ever occur for any of these Growth Hormone Releasing Peptides (GHRP) simply stop administering them for several days and this will remedy the effect.

  3. #3
    Canadian Bodybuilding Champ
    Join Date
    May 2007
    Location
    british columbia
    Posts
    2,248
    Rep Power
    15

    Default

    How long should Growth Hormone Releasing Peptides (GHRP) be used?
    In most studies no adverse side effects were reported with continuous use per the dosage limits in the above answer.

    Does Growth Hormone Releasing Hormone (GHRH) and Growth Hormone Releasing Peptides (GHRP) work together better?
    It is well documented and established that the concurrent administration of Growth Hormone Releasing Hormone (GHRH) and Growth Hormone Releasing Peptides (GHRP) results in synergistic release of growth hormone from pituitary.

    In other words if Growth Hormone Releasing Hormone (GHRH) contributes a growth hormone amount quantified as the number 2 and Growth Hormone Releasing Peptides (GHRP) contributed a growth hormone amount quantified as the number 4 the total growth hormone release is not additive (i.e. 2 + 4 = 6). Rather the whole is greater than the sum of the parts such that 2 + 4 = 12.

    Can Growth Hormone Releasing Hormone (GHRH CJC-1295) be used alone?
    The problem with using only Growth Hormone Releasing Hormone (GHRH) (even the stronger analogs) is that they are only effective when somatostatin is low (the growth hormone inhibiting hormone). So if you administer it in a trough (or when a growth hormone pulse is not naturally occurring) you will add very little growth hormone release. If however you administer it during a rising wave or growth hormone pulse (somatostatin will not be active at this point) you will add to growth hormone release.


    Can Growth Hormone Releasing Peptides (GHRP) be used alone?
    Yes. They are capable of creating a larger pulse of growth hormone on their own than Growth Hormone Releasing Hormone (GHRH) and they do this with much more consistency and predictability without regard to whether a natural wave or trough of growth hormone is currently taking place.

    What is a typical protocol for Growth Hormone Releasing Hormone (GHRH) and Growth Hormone Releasing Peptides (GHRP)?

    Studies have suggested the following:
    A typical conservation protocol would be:
    100-200mcg of Growth Hormone Releasing Peptides (GHRP)
    Approximately 5-7 days a week - subcutaneous injections

    This can be used once, twice, three or four times a day to make it more effective.
    When dosing multiple times a day at least 3 hours should separate the administrations.

    A more aggressive protocol would be:
    100-200mcg of Growth Hormone Releasing Peptides (GHRP) plus
    100-300mcg of Growth Hormone Releasing Hormone (GHRH).
    Approximately 5-7 days a week - subcutaneous injections

    This can be used once, twice, three or four times a day to make it more effective.
    When dosing multiple times a day at least 3 hours should separate the administrations.

    Studies suggest that a once a day dosing pre-bed will give a restorative amount of growth hormone while multiple dosing and/or higher levels will give higher growth hormone & IGF-1 levels which will lead to muscle gain, fatloss and/or injury repair.

    Should food be consumed before or after the injection of Growth Hormone Releasing Hormone (GHRH) and/or Growth Hormone Releasing Peptides (GHRP)?
    Studies have shown that administration should ideally be done on either an empty stomach or with only protein in the stomach. Fats and carbohydrates blunt growth hormone release. After administering the peptides wait about 20 minutes (no more than 30 but no less than 15 minutes) to eat. At that point the growth hormone pulse has reached its peak and you can eat what you want.

    Synthetic Growth Hormone

    What is Human Growth Hormone (HGH) Fragment 176-191?
    The HGH Fragment is a modified form of amino acids 176-191 at the C-terminal region of the human growth hormone (HGH). Studies have shown that it works by mimicking the way natural HGH regulates fat metabolism but without the adverse effects on insulin sensitivity (blood sugar) or cell proliferation (muscle growth) that is seen with unmodified HGH. Like unmodified GH, the HGH fragment 176-191 stimulates lipolysis (breaking down of fat) and inhibits lipogenesis (the formation of fatty acids and other lipids in the body).

    HGH fragment 176-191 is meant to be 12.5 times stronger than human growth hormone (HGH) for weight loss than standard human growth hormone (HGH).

    Of particular note is that in studies HGH fragment 176-191 had the ability to increase IGF-1 levels which translates into the fragments ability to give anti-aging effects.

    How much Human Growth Hormone (HGH) Fragment 176-191 should be used?
    In most studies favorable results have been shown with dosages between 500-1000mcg or 5-10mcg/kg split into multiple dosages per day.

    How long should Human Growth Hormone (HGH) Fragment 176-191 be used?
    In most studies no adverse side effects were reported with continuous use per the dosage limits in the above answer.

    What is a typical protocol for Human Growth Hormone (HGH) Fragment 176-191?
    Studies have suggested the following:
    A typical conservation protocol would be:
    250mcg in the morning plus
    250mcg pre lunch plus
    250mcg in the evening (pre-bed).
    Approximately 5-7 days a week - subcutaneous injections

    A more aggressive protocol would be:
    350mcg in the morning plus
    350mcg 30 minutes prior to training
    350mcg in the evening (pre-bed).
    Approximately 5-7 days a week - subcutaneous injections

    When dosing multiple times a day at least 3 hours should separate the administrations.

    Should food be consumed before or after the injection of Human Growth Hormone (HGH) Fragment 176-191?
    Studies have shown that administration should ideally be done on either an empty stomach or with only protein in the stomach. Fats and carbohydrates blunt growth hormone release. After administering the peptides wait about 20 minutes (no more than 30 but no less than 15 minutes) to eat. At that point the growth hormone pulse has reached its peak and you can eat what you want

  4. #4
    National Level Bodybuilder
    Join Date
    Aug 2010
    Posts
    591
    Rep Power
    6

    Default

    folli , cjc1295 dac ,,, 1gflr3 work ,, th rest bahh

  5. #5
    Full Registered Users.
    Join Date
    May 2009
    Location
    canada
    Posts
    4,002
    Rep Power
    0

    Default

    Great thread Rickerred and sweet post Physique thx!!

  6. #6
    Canadian Bodybuilding Champ
    Join Date
    Apr 2007
    Posts
    2,278
    Rep Power
    13

    Default So many peps

    Rick, what peptides are you interested in? There are many different types, I have exp in many of them I might be able to help.
    Truenutrition.com ---> where all top athletes/bodybuilders get their supplements (no customs/duty tax fee's at all)
    5% discount code for Canadians---> CANADABB

  7. #7
    Wannabe
    Join Date
    Nov 2011
    Location
    Nova Scotia, Halifax
    Posts
    113
    Rep Power
    3

    Default

    Hey there Jonny O, mostly looked at CJC-1295 and GHRP-6 or what ever will give the best results. The only thing about GHRP-6 is the hunger and being light headed some of the guys have mentioned.

    Thanks all for the input you answered a lot of questions for me.

  8. #8
    Provincial Level Bodybuilder
    Join Date
    Apr 2009
    Location
    Brampton
    Posts
    651
    Rep Power
    6

    Default

    Hi

    I am currently 2 weeks from my show and i am Using GHRP-6, HEX, FRAG and melanotan.
    Melanotan is AWESOME for getting color in your skin with minimal sunlight!!

    The Frag is helping alot with leaning me out.
    I think the GHRP-6 and Hex together is helping keep some muscle also.

    I will be going hard on them when I go in my off season With GHRP-6, hex and the new sermorlein
    I will have 2 years before my next show so hoping it will help me grow fast
    For Offseason and Contest Prep programs check out CanadianMuscleTeam.com
    Preparing for the 2012 cobourg invitational

  9. #9
    Muscle Bound
    Join Date
    Feb 2009
    Location
    Toronto
    Posts
    1,122
    Rep Power
    9

    Default

    Here is some interesting reading...

    GHRH (Growth Hormone Releasing Hormone) + GHRP (Growth Hormone Releasing Peptide) = 10 star GH Release (**********)

    GHRP (Growth Hormone Releasing Peptide aka Ghrelin-mimetic) = 3 star GH Release (***)

    GHRH (Growth Hormone Releasing Hormone) = 0 or 1 star GH Release (*)


    GHRPs (GHRP-6, GHRP-2, Hexarelin, Ipamorelin) are like cardiac shock paddles. You administer a GHRP and a pulse of GH is created. This is predictable and reliable across all normal people.

    GHRH creates no pulse. It only adds to what ever is happening naturally. If there is a pulse occurring then GHRH increases the GH release. If no pulse is occurring when GHRH is administered then it will have little effect on GH release.
    I can not speak for Dr. Crisler but he indicated that Sermorelin (GHRH) by itself was not very effective at raising IGF-1 levels. However when he added GHRP-6 with it at saturation dose (I believe administered together twice a day), IGF-1 levels increase by 1/3.

    This underscores the need for both a GHRH & a GHRP.

    IF you are 100% sure you have CJC-1295 (and the odds are against it) then because it is a long lasting GHRH (half-life measured in days) it will always be available which means during natural GH waves & troughs. So it behaves differently and its effectiveness in terms of absolute GH release is higher then the other forms of GHRH.

    CAVEAT - CJC-1295 raises base levels of GH not the pulses. It is possible that CJC-1295 never gives the somatotrophs sufficient time to reload stores of GH at the 100% level. Normally Somatostatin by stopping GH release activity gives the cells sufficient time to build up a big store of releasable GH. So CJC-1295 no matter how much GHRP you add may not be able to effect as strong a pulse as a GHRP + GHRH.

    There is no reason NOT to combine a GHRP such as GHRP-6 with your GHRH, no matter whether the form of GHRH is Sermorelin, modified GRF(1-29) or CJC-1295. There is only BIG benefit.

    On the flip side you can consistently and reliably effect GH pulsatile release with a GHRP alone. Without a GHRH the amplitude will not be synergistically higher. BUT it will be a strong pulse of GH release.

    One more quick point. An iu of synthetic GH is 333mcg of compound. Thats all. A unit of GH doesn't give the same effect across all normal people and even within a person there is variability.

    A far better measure is GH in plasma measured in many multiple intervals over a period of time. By sampling frequently you can determine the peak of GH in plasma and when it drops to baseline.

    You can then measure IGF-1 levels to determine the effect that THAT dosing had on increasing circulating levels.

    You can do the same thing with GHRH & GHRP.

    The problem people have is they are stuck on absolute levels of GH in circulation as being of paramount importance. It isn't.

    First it is free GH that is important. Anywhere from 10% to 90% may be bound at any given time with GH-Binding proteins or prolactin-binding proteins.

    Second it is pulsation that is important for growth not absolute levels. Pulses send communicative signals to the cells. GH is simply the ligand that gives form to the wave. GH has no other value except to be a part of a communication signal.

    The cells respond to this wave of GH by mediating events within the cell that are responsible for metabolism, protein synthesis, further ligand transcription & synthesis in the form of IGF-1 ...some of these signaling pathways in the cell carry messages to proliferate, differentiate or induce apoptosis . These intracellular pathways are common to many different tissue populations and respond to initiation from many different types of ligands binding to various receptors.

    This behavior is optimized by pulsation ...continuous GH desensitizes these pathways (and sends certain signals that are common to females to mediate certain events such as creation of specific liver enzymes)...

    So it is probable that I (and anyone who understands fully) could get more out of a small amount of GHRH + GHRP then someone who administers large amounts of GH. The validity of this statement is dependent on the use of other compounds...

    Finally to answer your question directly:

    I believe that if your CJC-1295 is modified GRF(1-29), coupled with GHRP-6, dosed as described you will achieve your goal of GH level (i.e. 4ius) and exceed both the quantity & quality of those growth optimizing events that THAT equivalent level of synthetic GH will be capable of mediating.




    This is an interesting study done in cattle. Apparently cattle get one 2 hour feeding a day.

    So one hour before the meal GHRH by itself or GHRP-6 by itself worked better then when administered by itself one hour post-meal. That is what we would expect.

    In addition one hour pre-meal the GHRH + GHRP-6 produced a larger pulse of GH together. This we would also expect.

    What is surprising and interesting is that taking GHRP-6 + GHRH together one hour post-meal produced a pulse of GH basically equivalent to the pre-meal pulse. In other words the synergy of the two peptides over came the meal refractory effect (where either one administered alone was unable).

    Perhaps a similar effect takes place in humans... i.e. even when the stomach is full (1 hour post-meal) GHRH+GHRP-6 creates an undiminished GH pulse.



    GH-releasing peptide-6 overcomes refractoriness of somatotropes to GHRH after feeding, C D McMahon, Journal of Endocrinology (2001) 170, 235–241

    ABSTRACT

    After a meal, somatotropes are temporarily refractory to growth hormone-releasing hormone (GHRH), the principal hormone that stimulates secretion of growth hormone (GH). Refractoriness is particularly evident when free access to feed is restricted to a 2-h period each day. GH-releasing peptide-6 (GHRP-6), a synthetic peptide, also stimulates secretion of GH from somatotropes. Because GHRH and GHRP-6 act via different receptors, we hypothesized that GHRP-6 would increase GHRH-induced secretion of GH after feeding. Initially, we determined that intravenous injection of GHRP-6 at 1, 3 and 10 ug/kg body weight (BW) stimulated secretion of GH in a dose-dependent manner.

    Next, we determined that GHRP-6- and GHRH-induced secretion of GH was lower 1 h after feeding (22.5 and 20 ng/ml respectively) than 1 h before feeding (53.5 and 64.5 ng/ml respectively; pooled (S.E.M.=8.5).

    However, a combination of GHRP-6 at 3 ug/kg BW and GHRH at 0.2 ug/kg BW synergistically induced an equal and massive release of GH before and after feeding that was fivefold greater than GHRH induced release of GH after feeding.




    Some terms:

    Natural GH is a blend of isoforms. Two of those forms are equally anabolic. One makes up the majority of natural GH release, weighs 22kda and is 191 amino acids long. The other weighs 20kda and has the 15 amino acids that interact with the prolactin receptor removed. The pharmaceutical companies chose to use the 22kda form for their drug. Noone makes a 20kda form.

    In addition nature stacks these forms so you get 22kda:22kda; 22kda:20kda; 20kda:20kda stacks. Noone exactly knows why. There are also some naturally occurring fragments that are released.

    Synthetic GH is simply the 22kda form chosen by the drug companies.

    Pulsatile release of natural GH is achieved by the hypothalamus (area of the brain) releasing the hormone GHRH (growth hormone releasing hormone) into the the pituitary where it binds to cells in the pituitary and causes the release of stores of GH isoforms to be released.

    Now the cells network and coordinated this release. They actually communicate and send a strong squirt of GH into the blood stream.

    The hypothalamus also creates a hormone called somatostatin which also binds to cells in the pituitary and shuts off GH release. This on/off interplay creates pulses and when we have "off" time the cells are quickly remaking GH from pieces it keeps lying around so that it is ready to release the next time GHRH comes calling.

    There is a third hormone called Ghrelin which comes from the gut and is a modulating hormone. It also binds to the pituitary and increases GHRH's positive effect and reduces Somatostatin's negative effect. The artificial mickers of Ghrelin are the GHRPs (growth hormone releasing peptides).

    GHRH if injected only has a really positive effect on GH release if naturally occurring somatostin isn't currently active. We have no real way of knowing though...

    GHRH works well in our bodies because it travels such a short distnce and is then used but if you inject it, it breaks down quickly (in minutes) and so analogs were created to resist this.

    The primary analog has 4 amino acids replaced so it increases the half-life to 30 minutes. This is often called tetra-substituted (4-sub) but it is what I refer to as modified GRF(1-29). A lot of people mistakenly call it CJC-1295.

    So if you inject modified GRF(1-29) you are happy because it will survive... it is a better form of GHRH BUT again if somatostatin is currently active then the GH pulse will not be strong.

    GHRPs, are needed to create a pulse. GHRPs come in several forms. GHRP-6, GHRP-2 and Hexarelin. All work the same way. The GHRPs blunt somatostatin and increase natural GHRH release. So if you inject a GHRP you create a pulse of GH which rises for 30 minutes, peaks and comes down within 2 hours. That mimics a natural pulse.

    So THAT is the time to take your modified GRF(1-29) (a better form of GHRH) because it will now work since somatostin isn't around.

    The studies find synergy between these two peptides. Together they create a strong pulse of GH.

    Growth Hormone Receptors, reside primarily on cells in the liver and they await the ligand GH. Now a strong pulse will send GH in mass so that a bunch binds at the same time to these receptors. When GH binds to a receptor it switches on a few events. One of those events is activating the Stat5b protein or intracellular pathway. This protein when activated moves to the nucleus of the cell and initiates transcription of proteins among them IGF-1.

    Stat5b needs time off and it is strongly activated after it gets a break.

    Synthetic GH administration, can occur intravenously. This allows for GH to mimic a pulse by immediately hitting the blood stream. binding to receptors and then even at high doses (20iu+) it is out within 2 hours.

    The other two forms intramuscularly and subcutaneously result in slower release profiles. The primary reason is that the molecule is large.

    So if you dose more then 4iu subcutaneously the release profile looks like an elevation more then a pulse and it starts to last for 3,4+ hours.

    Pulsing synthetic GH can be achieved by choosing 2iu, 3iu or 4iu (keep in mind intramuscular has a little faster release rate) and dosing so as to get a 2 hour rise followed by a 3 hour off time. This can be done 4 times a day or 5 times if you dose in the middle of the night.

    Some people prefer 2iu and squeeze in 6 doses in a 24 hour period. This is obviously an extreme way to do it but welcome to bodybuilding...

    Pulsing with GHRH/GHRPs - you can dose 250mcg of a GHRP (i.e. GHRP-6, GHRP-2 or Hexarelin) with 100mcg+ of modified GRF(1-29).

    100mcg of each is a minimal clinical dose but doses as high as 400mcg at a time have some effect.

    Obviously these peptides create pulses and no amount will interfere so dosing can be whatever.

    For instance a lady who is about 65 uses a tiny amount pre-bed (maybe 25mcg of each). She was crippled with bone pain and had to crawl up stairs. Prescription GH was of limited effect. The mod GRF(1-29)/GHRP-6 changed her life immediately. Now 6 months later she walks 2 miles a day and even breaks into a jog when pushing the grandkids stroller. Her doctor says her bone density is that of a young person. This is just an illustration... and for bodybuilding her dosing is not sufficient...

    The key though is to remind yourself that GH is just a communicative tool. It communicates different things depending on how it is released... it has zero value except for its role as a communicator.

    You use the GHRH/GHRP every time you want a pulse. You ALWAYS want one pre-bed. In men the biggest amount of GH release occurs at night. GH release and slow wave sleep are positively correlated. You increase/decrease one you increase/decrease the other. These peptides really increase deep restful sleep and I have been told by many that this alone is worth it.

    It takes just 100mcg of each to get this deeper sleep.

    You also want to dose PWO and in the morning. That is 3 times a day. You can go as many as 6 times a day (people do... they are a bit obsessive ).

    Combining synthetic GH and GHRH/GHRPs - The GHRH/GHRPs are know to act quicker then synthetic GH. By act I mean engage lipolysis if you are keeping insulin quiet and active enough to burn mobilized fatty acids but also strengthening connective tissue.

    I just wrote an article for Big A's whey protein product as an excuse to talk about what specific aspects, insulin, GH, IGF-1, IGF-1/BP3, androgens, blood flow, amino acid pool, thyroid hormones contribute towards protein metabolism.

    GH greatly contributes to decreasing muscle protein breakdown and preventing Leucine from being oxidized. I REALLY wanted people to see how these things work together and understand that growth hormone is not anabolic by itself but with insulin (which increases muscle protein synthesis) it is anabolic. It increases amino acid transport into muscle so insulin increased muscle protein synthesis will have a substrate to work with.

    So the GHRH/GHRPs work a little faster but you are limited to whatever available stores of GH you have to create a pulse. To get a higher pulse you add synthetic GH which is also now part of a natural blend.

    You would administer the GHRH/GHRP...let that pulse start going and 10 minutes later administer 2iu to 4iu of synthetic GH. That will create the biggest super-natural pulse that you can achieve and the body will see it as a big "natural" pulse.

    You can repeat this.

    Every day is effective. The reason EOD worked better then ED was because when you dose 12iu+ you need time off... think those graphs I referred you to.


    4.jpg

    With 4iu of synthetic GH and tapping out your natural stores you will saturate receptors pretty well.

    Insulin will increase GH receptors as well at low dose but at 8iu the benefit goes back to zero... this doesn't by any means mean you need to hold insulin below 8iu... it is just one of many many effects of insulin... and I just note it.

    Then after 5 hours you can do this again and then again. That is a far better way to use 12iu a day and with your own natural release you may end up above 20iu.

  10. #10
    Muscle Bound
    Join Date
    Feb 2009
    Location
    Toronto
    Posts
    1,122
    Rep Power
    9

    Default

    Some more info...
    Sermorelin as an Alternative to hGHfor Treating GH Insufficiency of Aging
    Richard F. Walker, Ph.D., R.Ph., Executive Director, Society for Applied Research in Aging (SARA)(www.agesociety.org)
    http://youthfulagingcenter.com/Sermo...esentation.pdf

    Sermorelin Q & A
    http://www.nationwidesi.com/forms/sermorelin_qanda.pdf


 
Page 1 of 2 12 LastLast

Similar Threads

  1. Peptides
    By Talo in forum Hormone Replacement Therapy - HRT
    Replies: 5
    Last Post: 17-04-2011, 10:49 PM
  2. WORK -barely time to work out
    By monkey in forum Rants & Raves
    Replies: 16
    Last Post: 24-08-2010, 05:00 AM
  3. peptides
    By grifter in forum Hormone Replacement Therapy - HRT
    Replies: 4
    Last Post: 04-05-2010, 03:26 PM

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •