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Oxandrolone excretion: effect of caffeine dosing
Laboratório de Análises de Dopagem, IDP, Lisboa, Portugal.
Laboratorio Antidoping, Federazione Medico Sportiva Italiana, Roma, Italy.
Abstract
Recent information obtained as a result of law enforcement activities in Portugal has indicated that a particular group of athletes is likely using caffeine in conjunction with oxandrolone. In this paper we present our work to investigate the possible effect of this co-administration. Therefore excretion studies were undertaken to determine what effects were produced and what was their extent. In these studies a single dose of oxandrolone was given, with and without the application of caffeine. A noticeable effect was observed upon both the clearance of oxandrolone and the metabolism to epioxandrolone. The concentration of both oxandrolone and epioxandrolone excreted in the urine increases substantially with caffeine intake. The results are discussed and assessed.
Introduction
Caffeine use was prohibited by the IOC in 1984, initially with a 15 µg/mL cut-off. In 1985 this was reduced to 12 µg/mL. In 2004 the World Anti-Doping Agency (WADA) did not include caffeine on the list of prohibited substances. Some performance-enhancing effects of caffeine as a stimulant and diuretic have been well described. Although Flenker U. described an IRMS method which differentiates caffeine from synthetic or natural origin, it is problematic for the laboratories in their usual screening methods to control the abuse of caffeine and to distinguish it from normal intake. Oxandrolone (17β-hydroxy-17α-methyl-2-oxa-5α-androstane-3-one) has been described as enhancing protein synthesis and lean muscle mass7 , advantageous effects which would prompt athletes to abuse it. This synthetic 2-oxasteroid pharmacologically related to testosterone was first prepared in 1962. It is purported to have a pronounced anabolic effect yet, apparently, with much lower androgenic activity, thereby significantly reducing virilization effects.
Experimental
Oxandrolone (400 µg) was orally administered to a regular drinker of caffeine (the equivalent of 3 espresso coffees per day). A blank and all urines post-administration were collected for 70 hours. The second study took place 4 days after the first study. The same dose of oxandrolone was given orally to the same subject combined with 300 mg of caffeine. All urines were collected for 70 hours....
Results
Figures 1 and 2 show the excretion profiles of oxandrolone and epioxandrolone, with and without caffeine dosing. The maximum excretion rate of oxandrolone was 10 ng/min; but with caffeine this increased to 150 ng/min. Similarly, for epioxandrolone the maximum rate was 0.9 ng/min and 19 ng/min with caffeine. The maximal excretion rates occurred at less than 4 h and less than 6 h, respectively. The caffeine excretion shows a maximum concentration of ~18 µg/mL at 4.7 h (Fig. 3).
Note the difference between these two graphs. When a single, large dose of caffeine is administered, the rate of absorption and excretion appears to follow that of the caffeine...creating two distinct pulses of oxandrolone. While the duration of these pulses is not as short as say a GH pulse, this is still worth noting.
Conclusion
Our data show that caffeine alters the excretion profile of oxandrolone. With 300 mg of caffeine, there were very large increases (about 20 times) in the amount and rate of excretion for both oxandrolone and epioxandrolone. However whereas total oxandrolone increased more than 20-fold, total epioxandrolone increased only about 15-fold. The patterns of oxandrolone and epioxandrolone excretion appear to follow the caffeine excretion pattern. We postulate that caffeine increases the bioavailability of oxandrolone, probably by increasing gut emptying. Practically this means that similar concentrations/effects may be achieved using lower dosages. Caffeine is reported to accelerate absorption of some drugs (e.g. paracetamol).3 To determine if there is an additional metabolic effect, alternative routes of administration with/without caffeine dosing should be tested and both blood and urine collected. Other anabolic steroids should also be investigated. Finally, only one sample (300 mg caffeine dose) exceeded the former 12 µg/mL threshold.
This study ought to open some eyes as to the potential for certain compounds such as caffeine to be able to increase the bio-availability, absorption, and excretion rates of other compounds. For our purposes, we can use this approach to utilize compounds such as Oxandrolone without extended periods of it floating around. You could take oxandrolone with a preworkout caffeine dose, have oxandrolone active during and post workout, and then have most of it excreted by the end of the day. The next morning when your body is producing testosterone, there will not be significant amounts of oxandrolone around to suppress production, thus starting the cycle over again.
Who knows how long you could go before the levels build up to create a trough of OX in the blood, leading to some suppression, but hopefully this can open up the discussion to experiences and ideas about how we can best find the balance of supplementation without going overboard and causing ourselves undue harm. I like the idea that a smaller dose can be more effective for a short period of time.
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Aromasin th anti-E, is the winner of them all,, since organs are not affected negatively
In fact anti-estrogen are not essential unless you're taking too much for thyself, our beloved insane cycle
after all T3 mgf 1gf testo,, growth hormone and insulin are self-made by th endogenous system playing like a orchestra
but the body does not manufacture anti estrogen
but it is made by nature,, the indole-tre-carbinol in broccoli
despite modern world technological advances , the estrogen is not biodegradable so it accumulates
in industrial food, the atmosphere, and water ..it's xenoestrogenic to a point
that's why the progesterone steal in women is an established plurality
the bodybuilder living at 100% and her beautiful woman is fabulous and wrinkle,
addiction to sugars, stretch marks at 19, menopause at 36 .. infertility is th new generation challenge
and the change of lifestyle is powerful ,, body is beautifully resilient
you must eat organic to a ratio and own a UV water filter to counter the chlorine disrupting our precious nutrients assimilation
organic food is quite costly,.. but hey if you're capable of buying a bottle of anavar at xzy $ cost, you can contemplate in your fridge a saxy grass-fed beef
but hey ,, why be fond of Health in excess? in fact steroids alter lots of chemicals and our fierce pre workout stimulants also
cortisol, liver, endothelial health, nutrition and cell metabolism is more complicated than inject 1cc of enanthate and wait something happen
So the plan is to endocrine damage intelligently and responsibly. no matter what they re always will be metabolic damage , it call " th glycation of ageing
you track n feel the body biological inner stamina and when those chronological hormone made you feel not so good , like trensomia , anger out of nothing , fighting with peoples , it not roids rage.. it electrolytes deficiencies ,, voila ; )
therefore,, cycle need intrinsic morals, mental and protective knowledge of mortal organ in a young adult invincible mindset
stable cycle = stable relationship = smart ethic of a mature bodybuilder
meaning you will not chew your anadrol til you puke , there's result and self destruction
the importance in a cycle to steal a beautiful metaphor of Mathieu Bouchard
not too much farting, burping, snoring, too regular bathroom trips. it shouldn't smell like fermenting cancer bcoz that means your excrement toxify th body
clean tongues better glp1 sweet sensor that send pre signal to pancreas
clean teeth , for th periodontal ligaments between teeth n gum control dynamic gait
the stomach is immunity and assimilation of the food, it what you need for muscle growth
if buying 100% bionic great area supplements set aside a 25% budget to take care of yourself
we all know our personal weakness, and google a great tool on health knowledge for ?homeostasis n equilibrium"
dosing cycles is personal, the potential of hypertrophy are written since a long time,, in RNA DNA genetic code and breastfeeding duration
some will do heroically well with not much and the others will pedal to metal
the important thing is to feel good because if you need xanax to take trenbolone acetate
its going to hurt your case,, if can?t smile n have fun growing , lower th dose ,
it your own body talking to ya. poor brain no well being , brain's job is to take care of you,
androgen wisely with inner potential cooperation ,, or growth potential might be compromised or th longevity in the sport is ,,
thank you
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read *****
Nonsteroidal selective androgen receptor modulator ***Ostarine*** in cancer cachexia.
Zilbermint MF1, Dobs AS.
Author information
Abstract
Cancer cachexia is a complex syndrome, affecting up to 60% of the approximately 1.4 million patients diagnosed with cancer each year in the USA. This condition is characterized by progressive deterioration of a patient's nutritional status, weight loss, anorexia, diminished quality of life and increased mortality and morbidity. Current therapy with progestational, anti-inflammatory and anabolic agents is often ineffective and has a large number of undesirable effects. The newly developed nonsteroidal selective androgen receptor modulator Ostarine has demonstrated promising results in Phase I and II clinical trials, increasing total lean body mass, enhancing functional performance and decreasing total tissue percent fat.
*******This selective androgen receptor modulator may have the ability to perform as a potent anabolic agent with minimal side effects on other organs ******
(prostate and hair follicles), thus presenting a new strategy in managing cancer cachexia. However, more extensive data is required before its efficacy is confirmed.
PMID: 19852734 [PubMed - indexed for MEDLINE]
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gestation , vibration , gene pool , birth technique , breastfeed , morphospychology, caracterology , pre crawl , crawling phase , primitive reflexes, postural imprint by proprioception self learning meaning vision audition taste swallowing attention imagination breathing laterality ( left-right brain hemisphere communication ) neuroplasticity meaning peripheral nerves talent of modulation from interospective/exterospective haspic system which mean multi fractal bio tensegraity talent which mean stability neurological function , omg i just jerk off in my pants , then adaptive lifestyle for endocrine hormonal balancing repercussions , from all this motor behaviour follow
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In the month leading up to a baby's birth, the umbilical cord pulses with the equivalent of at least 300 quarts of blood each day, pumped back and forth from the nutrient- and oxygen-rich placentato the rapidly growing child cradled in a sac of amniotic fluid. This cord is a lifeline betweenmother and baby, bearing nutrients that sustain life and propel growth. Not long ago scientists thought that the placenta shielded cord blood — and the developing baby — from most chemicals and pollutants in the environment. But now we know that at this criticaltime when organs, vessels, membranes and systems are knit together from single cells to finishedform in a span of weeks, the umbilical cord carries not only the building blocks of life, but also asteady stream of industrial chemicals, pollutants and pesticides that cross the placenta as readilyas residues from cigarettes and alcohol. This is the human "body burden" — the pollution in people that permeates everyone in the world, including babies in the womb.
Of the 287 chemicals we detected in umbilical cord blood, we know that 180 cause cancer inhumans or animals, 217 are toxic to the brain and nervous system, and 208 cause birth defects or abnormal development in animal tests. The dangers of pre- or post-natal exposure to thiscomplex mixture of carcinogens, developmental toxins and neurotoxins have never been studied
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FEMALE BRAIN
1. Anterior Cingulate Cortex (ACC): Weighs options, makes decisions. Its the worry-wort center, and its larger in women than in men.
2. Prefrontal Cortex (PFC): The queen that rules the emotions and keeps them from going wild. It puts the brakes on the amygdala. Larger in women, and matures faster in teen girls than in boys by one to two years.
3. Insula: The center that processes gut feelings. Larger and more active in women.
4. Hypothalamus: The conductor of the hormonal symphony; kicks the gonads into gear. Starts pumping earlier at puberty in females.
5. Amygdala: The wild beast within; the instinctual core, tamed only by the PFC. Larger in men.
6. Pituitary Gland: Produces hormones of fertility, milk production, and nurturing behavior. Helps turn on the mommy brain.
7. Hippocampus: The elephant that never forgets a fight, a romantic encounter, or a tender moment and wont let you forget it, either. Larger and more active in women.
Estrogen the queen: powerful, in control, all consuming; some times all business, sometimes an aggressive seductress; friend of dopamine, serotonin, oxytocin, acetylcholine, and norepinephrine (the feel-good brain chemicals).
Progesterone in the background but a powerful sister to estrogen; intermittently appears and sometimes is a storm cloud reversing the effects of estrogen; other times is a mellowing agent; mother of allopregnenolone (the brains Valium, i.e., chill pill).
Testosterone fast, assertive, focused, all-consuming, masculine; forceful seducer; aggressive, unfeeling; has no time for cuddling.
The ones your doctor may not know about that also affect a womans brain
Oxytocin?fluffy, purring kitty; cuddly, nurturing, earth mother; the good witch Glinda in The Wizard of Oz; finds in help- ing and serving; sister to vasopressin (the male socializing hormone), sister to estrogen, friend of dopamine (another feel-good brain chemical).
xv
The Cast of Neuro-Hormone Characters Cortisol frizzled, frazzled, stressed out; highly sensitive,
physically and emotionally.
Vasopressin secretive, in the background, subtle aggressive male energies; brother to testosterone, brother to oxytocin (makes you want to connect in an active, male way, as does oxytocin).
DHEA reservoir of all the hormones; omnipresent, pervasive, sustaining mist of life; energizing; father and mother of testosterone and estrogen, nicknamed the mother hormone, the Zeus and Hera of hormones; robustly present in youth, wanes to nothing in old age.
Androstenedione, the mother of testosterone in the ovaries; supply of sassiness; high-spirited in youth, wanes at menopause, dies with the ovaries.
Allopregnenolone the luxurious, soothing, mellowing daughter of progesterone; without her, we are crabby; she is sedating, calming, easing; neutralizes any stress, but as soon as she leaves, all is irritable withdrawal; her sudden departure is the central story of PMS, the three or four days before a womans period starts.

Hormones can determine what the brain is interested in doing. They help guide nurturing, social, sexual, and aggressive behaviors. They can affect being talkative, being flirtatious, giving or attending parties, writing thank-you notes, planning childrens play dates, cuddling, grooming, worrying about hurting the feelings of others, being competitive, masturbating and initiating sex.
More than 99 percent of male and female genetic coding is exactly the same. Out of the 30000 genes in the human genome, the less than one percent variation between the sexes is small. But that percentage difference influences every single cell in our bodies from the nerves that register pleasure and pain to the neurons that transmit perception, thoughts, feelings, and emotions.
To the observing eye, the brains of females and males are not the same. Male brains are larger by about 9 percent, even after correcting for body size. In the nineteenth century, scientists took this to mean that women had less mental capacity than men. Women and men, how- ever, have the same number of brain cells. The cells are just packed more densely in women cinched corset like into a smaller skull.
For much of the twentieth century, most scientists assumed that women were essentially small men, neurologically and in every other sense except for their reproductive functions. That assumption has been at the heart of enduring misunderstandings about female psychology
New brain science has rapidly transformed our view of basic neurological differences between men and women. Earlier scientists could investigate these differences only by studying the brains of cadavers or the symptoms of individuals with brain damage. But thanks to advances in genetics and noninvasive brain-imaging technology, there?s been a complete revolution in neuroscientific research and theory. New tools, such as positron-emission tomography (PET) and func- tional magnetic resonance imaging (fMRI) scans, now allow us to see inside the human brain in real time, while its solving problems, pro- ducing words, retrieving memories, noticing facial expressions, estab- lishing trust, falling in love, listening to babies cry, and feeling depression, fear, and anxiety.
As a result, scientists have documented an astonishing array of structural, chemical, genetic, hormonal, and functional brain differences between women and men.
Though we live in the modern urban world, we inhabit bodies built to live in the wild, and each female brain still carries within it the ancient circuitry of her strongest foremothers, engineered for genetic success but retaining the deeply wired instincts developed in response to stress experienced in the ancient wild. Our stress responses were designed to react to physical danger and life- threatening situations. Now couple that stress response with the modern challenges of juggling the demands of home, kids, and work without enough support, and we have a situation in which women can perceive a few unpaid bills as a stress that appears to be life- threatening. This response impels the female brain to react as though the family were endangered by impending catastrophe. The male brain will not have the same perception unless the threat is of immediate, physical danger. These basic, structural variances in their brains lay the groundwork for many everyday differences in the behavior and life experiences of men and women.
Males and females have the same average level of intelligence, but the female brains reality has often been misinterpreted to mean that it is less capable in certain areas, such as math and science. In January 2005, Lawrence Summers, then president of Harvard University, shocked and enraged his colleagues and the public when in a speech to the National Bureau of Economic Research he said: It does appear that on many, many different human attributes ,mathematical ability, scientific ability there is relatively clear evidence that whatever the difference in means which can be debated there is a difference in the standard deviation, and variability of a male and a female population. And that is true with respect to attributes that are and are not plausibly, culturally determined. The public surmised that he was saying that women are therefore innately less suited than men to be top-level mathematicians and scientists.
Judging from current research, Summers was and wasnt right. We now know that when girls and boys first hit their teen years, the difference in their mathematical and scientific capacity is nonexistent. Thats where he was wrong. But as estrogen floods the female brain, females start to focus intensely on their emotions and on communication talking on the phone and connecting with their girl- friends at the mall. At the same time, as testosterone takes over the male brain, boys grow less communicative and become obsessed about scoring in games, and in the backseat of a car. At the point when boys and girls begin deciding the trajectories of their careers, girls start to lose interest in pursuits that require more solitary work and fewer interactions with others, while boys can easily retreat alone to their rooms for hours of computer time.
Common sense tells us that boys and girls behave differently. We see it every day at home, on the playground, and in classrooms. But what the culture hasnt told us is that the brain dictates these diver- gent behaviors. The impulses of children are so innate that they kick in even if we adults try to nudge them in another direction. One of my patients gave her three-and-a-half-year-old daughter many unisex toys, including a bright red fire truck instead of a doll. She walked into her daughters room one afternoon to find her cuddling the truck in a baby blanket, rocking it back and forth saying, Dont worry, little truckie, everything will be all right.
This isnt socialization. This little girl didnt cuddle her truckie because her environment molded her unisex brain. There is no unisex brain. She was born with a female brain, which came complete with its own impulses. Girls arrive already wired as girls, and boys arrive al- ready wired as boys. Their brains are different by the time they?re born, and their brains are what drive their impulses, values, and their very reality.
Imagine for a moment that you are in a microcapsule speeding up the vaginal canal, hitting warp drive through the cervix ahead of the tsunami of sperm. Once inside the uterus, youll see a giant, undulating egg waiting for that lucky tadpole with enough moxie to penetrate the surface. Lets say the sperm that led the charge carries an X and not a Y chromosome. Voila, the fertilized egg is a girl.
If youre a girl, youve been programmed to make sure you keep so-cial harmony. This is a matter of life and death to the brain, even if its not so important in the twenty-first century.
Drama, Thats whats happening in a teen girls life and a teen girls brain. Mom, I so totally cant go to school. I just found out Brian likes me and I have a huge zit and no concealer. OMG, How can you even think Ill go, Homework? I told you Im not doing any more until you promise to send me away to school. I cant stand living with you for one more minute. No, Im not done talking to Eve. It has not been two hours, and Im not getting off the phone. This is what you get if you have the modern version of the teen girl brain living in your house.
The teenage years are a turbulent time. The teen girls brain is sprouting, reorganizing and pruning neuronal circuits that drive the way she thinks, feels, and acts and obsesses over her looks. Her brain is unfolding ancient instructions on how to be a woman. During puberty, a girls entire biological raison detre is to become sexually desirable. She begins judging herself against her peers and media images
Many women find biological comfort in one anothers company, and language is the glue that connects one female to another. No surprise, then, that some verbal areas of the brain are larger in women than in men and that women, on average, talk and listen a lot more than men. The numbers vary, but on average girls speak two to three times more words per day than boys. We know that young girls speak earlier and by the age of twenty months have double or triple the number of words in their vocabularies than do boys. Boys eventually catch up in their vocabulary but not in speed or overlapping speech. Girls speak faster on average, especially when they are in a social setting
Women, researchers have found, also look for mates who are, on average, at least four inches taller and three and a half years older. These female mate preferences are universal. As a result, scientists conclude, theyre part of the inherited architecture of the female brains mate choice system and are presumed to serve a purpose.
For the human mother, the lovely smells of her newborns head, skin, poop, spit up breast milk, and other bodily fluids that have washed over her during the first few days will become chemically imprinted on her brain?and she will be able to pick out her own babys smell above all others with about 90 percent accuracy. This goes for her babys cry and body movements, too. The touch of her babys skin, the look of its little fingers and toes, its short cries and gasps all are now tattooed on her brain. Within hours to days, overwhelming protectiveness may seize her. Maternal aggression sets in. Her strength and resolve to care for and protect this little being completely grab the brain circuits.
Women know things about the people around them they feel a teen- age child?s distress, a husbands flickering thoughts about his career, a friends happiness in achieving a goal, or a spouses infidelity at a gut level.
Gut feelings are not just free-floating emotional states but actual physical sensations that convey meaning to certain areas in the brain. Some of this increased gut feeling may have to do with the number of cells available in a womans brain to track body sensations. After puberty, they increase. The estrogen increase means that girls feel gut sensations and physical pain more than boys do. Some scientists speculate that this greater body sensation in women punches up the brains ability to track and feel painful emotions, too, as they register in the body. The areas of the brain that track gut feelings are larger and more sensitive in the female brain, according to brain scan studies. Therefore, the relationship between a womans gut feelings and her intuitive hunches is grounded in biology.
If you are a man you may be surprised to learn that there are more than 400 different human emotions. If youre a woman you probably knew that already.
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gestation since maternal stress have a womb recorded history , gene transcription , neurobiology of th will , toxic and pollution now do exist in th umbilical chord, epigenetic caGloball on talents n pathology , vibration , string theory , oscillation , gene pool , birth technique have micro biota influence of th guts, breastfeed duration strengten th winner chance , neuroplasticity , morphospychology, caracterology , pre crawl , crawling phase , primitive reflexes, postural imprint by proprioception self learning meaning vision audition taste swallowing attention imagination breathing laterality ( left-right brain hemisphere communication ) neuroplasticity in th sense of peripheral nerves talent of modulation from interospective/exterospective haspic system which mean multi fractal bio tensegraity talent which mean stability neurological function, thinking primitive reflex onto postural ontogeny make th way you move today , then adaptive lifestyle for endocrine hormonal balancing repercussions , where functional hormonal balancing need to be follow , from all this motor behaviour follow , chaos is freedom , freedom is poetry , and behavior is identity , confusion is in ubiquity , no drive, no will , when brain embrace th chaos in confidence , limitless are possibilities , after law of physic , chemistry then biology , pre anticipation of behavior may lead to suicide where will as a end , pride and shame , are decision making of neuroscience , on physic , human are techically proven to made out of stars , dust micro particles , but where does freedom lay is birth , on a gene pool man as 50% close to a banana in th tree of life , if now we can print 3d stem cells , we live in th birth of artificial intelligence , if glial can neurogenesis axon neuron damage , if immuno modulation can alter positively genetic repercussion outcome , think what you will become make now more sense , to even realistic of rationality , if neuron can go where your thought plan, th body can sure healing th self, it might sound like spirituality , where you draw th law of science n religion in a physical somatic sense of plural philosophy , if all of inter connective of past emotion had lead today to become a bodybuilder , where law of organization have defining stature repercussion on body composition , it shall be th head position where all science collide since activities n exercises , is physic , gravitational energy , time between reps , hormones and synaptic neuro transmittors at exhaustive ratio where the decision making fighting th failure of th competitive mindset , equilibrium n homeostatic law converge in where th thin line of self destruction and be th elite shall be , health cant come boundaries, gene can lay a fortunate myostatin level, imprinting talent of coordination will enhance growth potential , in obsessive planification we can all positively place at a top 5 national rank , it humility to envision ; turn th ordinary men in a contemplative winning state , knowledge as a sense of gift for th hard worker , and hard work never fail , free will might fight reduction against metastability but cognition lead th upcoming result , and bodybuilder care about th present , th future and th prejudging precise time of plan appearance , since i dare try connection dots of infancy to geriatrics n rehabilitation , lay body composition come a dear fun escapade , after all what normal in a extreme bodybuilding contest prep ,,,
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Great posts BLP.Any need for DHEA with TRT?
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I AM DEEPLY .. DEEPLY TO DIE TOMORROW AND MY LIFE PERSONAL GOAL WILL HAD BEEN MADE,
I JUST FREAKING ENTER "GH15 HALL OF FAME" !!!!!!!!!!!!!!!!!!!
for me so far after near 40 years of my life n been dabbling in th enhancement unique world for 15 years it my biggest existential glory ever ,
i will like to thank gh15 himself , gh15ers members , christ aceto , doc connelly , dan duchaine, john romano , john meadows , palumbo , mike arnold , heavyiron , EAS n th body for life , MD , RX , AS , MK , canadabbing , physiquextreme aaron singerman , derek anthony , dabtrue , salim satir , matt porter , claude groulx , neil gus, mat boule , paul check , darren oliver , gear up podcast , guy voyer , phil hernon , doc bricot
and all BLP readers since 2006 ,
a major thank you , for me it my own , my academy award, i just win OLYMPIA
I am far from done i am embarking in another journey , a book that will take me 10 years to write n will be release feb 2026 on a free blog download, for once i start connecting th dots in a logical stance , this is th day ,
BLP truly born .
THANK YOU , victory fell good , BOOM
https://www.youtube.com/watch?v=p0OC173kS2k
“The world needs dreamers and the world needs doers But above all the world needs dreamers who do.”
