IGF-1 LR3

[Tbag]

Will be running it for the first time in the next couple of weeks, just looking for everyones input on using it, dosing, dosing schedule etc. There seems be alot of different idea's........

[pw154]

I run it around 50mcg pre workout pinned IM. Makes for a GREAT pump / increased glycogen retention

[Tbag]

hmm i've read mostly that people take it post workout, bump for answers.

[zziggzzigg]

hmm i've read mostly that people take it post workout, bump for answers.

I always did it pre-workout too, it's been a year since I did it last but I feel like I made some gains that I wouldn't have otherwise and have held on to the gains

[Tbag]

Yeah thats what I've heard from a few people, wonder why its not more poplular than it is. Excited to give it a go.....

[Praetorian]

Will be running it for the first time in the next couple of weeks, just looking for everyones input on using it, dosing, dosing schedule etc. There seems be alot of different idea's........


Works great as a GDA (glucose disposal agent) hence the good pumps etc but you get zip for growth on it. Patrick Arnold did an entire blurb on this...its useless for growth...if you want to use IGF for growth you need IGF-1 without the LR3...its difficut to find, expensive and you need to use it multiple times daily.
P

[ironwill]

Works great as a GDA (glucose disposal agent) hence the good pumps etc but you get zip for growth on it. Patrick Arnold did an entire blurb on this...its useless for growth...if you want to use IGF for growth you need IGF-1 without the LR3...its difficut to find, expensive and you need to use it multiple times daily.
P
Do you believe it causes hyperplasia as some state??? Are Site injects are totally useless ?
I havent tried, dont think i will, just for educational purposes at this point....

[Tbag]

Can you expand on that please, how does it work differently?


Works great as a GDA (glucose disposal agent) hence the good pumps etc but you get zip for growth on it. Patrick Arnold did an entire blurb on this...its useless for growth...if you want to use IGF for growth you need IGF-1 without the LR3...its difficut to find, expensive and you need to use it multiple times daily.
P

[pw154]

Can you expand on that please, how does it work differently?It's an entirely different peptide. They modified the amino acid chain by adding the LR3 which causes the peptide not to bind to IGF binding proteins. This causes it to be active in the body for a lot longer than IGF-1 as its relatively short lived; it either attaches to a receptor, or binds to IGFBP-3 and it's gone. LR3IGF-1 does not do this. It floats around in the bloodstream until it binds to a receptor or is eventually eliminated by the liver. By changing the amino acid chain you are essentially changing the peptide entirely, which is why they work differently. That said, I still think there is use for the LR3 version which is why I still incorporate it. Like Praetorian said it makes for a GREAT (albeit expensive) GDA. It's awesome for PCT and bulking as it allows you to eat an excess of carbohydrates without storing additional adipose. It also makes me vascular as hell. It also has the ability to heal injuries at a faster rate than they would naturally which I theorize helps with recovery as well. Hyperplasia not so much though; you need HGH+Slin for that.

[Praetorian]

Can you expand on that please, how does it work differently?

Here is the scientific reasoning from Patrick Arnold.

IGF-1 vs IGF-1LR3

Long r3 has a SHORTER half life because it cannot bind to serum binding proteins. IGFBP3 is a major binding protein that acts as a stable reservoir of IGF-1, delivering it to target tissues where local proteases free up the hormone

LongR3 cannot bind to IGFBP3 so it is more quickly cleared. This makes it not the best choice for sustained systemic activity, but it also makes it the preferred choice for site injections for things such as connective tissue repair.

regular IGF-1 is best coadministered with GH

So in laymans terms if you want muscle growth use IGF-1 not IGF-1LR3.

P

[Praetorian]

IGF-1 yes...IGF-1 LR3 doesnt appear to. Site injection for connective tissue repair only...muscle growth no.
P

[pw154]

hmm i've read mostly that people take it post workout, bump for answers.Because it does not bind to IGFBP-3 and is long-acting, you can take it pre-workout. Just beware that it does mimic insulin in its action (hence Insulin-Like Growth Factor) so be sure to eat a lot of carbs pre-workout or have a intraworkout carbohydrate drink on hand.

[Praetorian]

Because it does not bind to IGFBP-3 and is long-acting, you can take it pre-workout. Just beware that it does mimic insulin in its action (hence Insulin-Like Growth Factor) so be sure to eat a lot of carbs pre-workout or have a intraworkout carbohydrate drink on hand.

You are misinterpreting things...see below again....by PA.

Long r3 has a SHORTER half life because it cannot bind to serum binding proteins. IGFBP3 is a major binding protein that acts as a stable reservoir of IGF-1, delivering it to target tissues where local proteases free up the hormone

LongR3 cannot bind to IGFBP3 so it is more quickly cleared. This makes it not the best choice for sustained systemic activity, but it also makes it the preferred choice for site injections for things such as connective tissue repair.

P

[pw154]

Long r3 has a SHORTER half life because it cannot bind to serum binding proteins. IGFBP3 is a major binding protein that acts as a stable reservoir of IGF-1, delivering it to target tissues where local proteases free up the hormoneReally? I've read Gropep studies that stated the LR3 half life to be around 20-30 hours. huIGF-1 is cleared within 5-10 minutes, which is why you need to take multiple injections daily at very high doses.... correct me if I have the wrong train of thought here

[Praetorian]

I believe the studies you've read are in vitro. I am not a chemist so Im not going to theorize...this topic has been debated to death on MD with PA...I would have to side with him on this as the anecdotal evidence backs it up as well.
If you like I believe ha has a Q&A thread there you can ask him.
P

[pw154]

IGFBP3 is a major binding protein that acts as a stable reservoir of IGF-1, delivering it to target tissues where local proteases free up the hormone

See I thought IGFBP3 in essence deactivated the peptide entirely:


Over 90% of IGF-1 in the blood is bound to IGF binding protein-3 (IGFBP-3), which inhibits IGF-1 action by making it unable to bind to cell surface IGF-1 receptors. Less then 1% of the IGF-1 circulating is in an unassociated form. (1)

(1) Moschos SJ, Mantzoros CS. The role of the IGF system in cancer: from basic to clinical studies and clinical applications. Oncology, 2002;63:317–32.

[pw154]

I believe the studies you've read are in vitro. I am not a chemist so Im not going to theorize...this topic has been debated to death on MD with PA...I would have to side with him on this as the anecdotal evidence backs it up as well.
If you like I believe ha has a Q&A thread there you can ask him.
PYes the studies Ive read are in vitro, as no LR3 studies have or ever will be done on humans....

but from my own personal experiences with the peptide I've found that it is rather long lived; ie, by administering it three times a week roughly 48 hours apart, I was able to sustain a full and vascular/pumped appearance all week. I also had slight hypoglycemic symptoms if I kept my carbs too low which led me to believe that LR3s GDA properties were still effective - even 24+ hours after administration

[Praetorian]

See I thought IGFBP3 in essence deactivated the peptide entirely:

It doesnt deactivate it....it delivers it... but IGF1-LR3 cannot bind to IGFBP3....as per PA's explaination. Thus for it to be effective as PA states...IGFBP3 is a major binding protein that acts as a stable reservoir of IGF-1, delivering it to target tissues where local proteases free up the hormone...this does not happen with LR3...hence no action..no delivery to the cell tissue.
P

[Praetorian]

Yes the studies Ive read are in vitro, as no LR3 studies have or ever will be done on humans....

but from my own personal experiences with the peptide I've found that it is rather long lived; ie, by administering it three times a week roughly 48 hours apart, I was able to sustain a full and vascular/pumped appearance all week. I also had slight hypoglycemic symptoms if I kept my carbs too low which led me to believe that LR3s GDA properties were still effective - even 24+ hours after administration

You are getting an insulin response...ie the GDA property. This has nothing to due with systemic anabolic activity.
P