Proviron toxicity

[deleteduser0002]

From what I've read Proviron is a lot less toxic to the liver than other AAS and as such can be run much longer without much concern. But does anyone have any info on how long?

I'm currently running GH 2IU's a day /Testosterone Enanthate 500mg a week and Proviron at 50mg a day. I've been on the GH for 6-7 weeks now and just started the Test/Proviron a little over 2 weeks ago. I Plan on running it for about 15 weeks then switching over to Prop/Var/GH for another 7 weeks or so. I know that Var can be run 12 week cycles pretty safely as a result of its low toxicity as well, but with the above cycle I'll be on either Proviron or Var for over 5 months. Anyone have any data showing Proviron is too toxic for this? I haven't found any real data either way.

[faller]

Funny, i asked this same question a while back on another board. I'm on HRT and was curious as to how long i could keep takeing Proviron. No one seemed to know, so i'd be interested in the answer as well..

[Mr.Freeze]

The whorst thing that could happen from too much Proviron is a perpetual hard one!lol:D

[ergie]

Proviron is very mild, people go on it for years straight

[gustavo77]

I am looking but have yet to find a clinical study that clearly displays long term toxicity issues with proviron but i found this little piece info that may help:

"Mesterolone is an oral alkylated steroid. If used throughout a longer cycle it may elevate liver values slightly. However, this would be far less than would be expected with a 17-alpha-alkylated steroid. Its not quite as toxic since its not alkylated in the same fashion, but at the 1 position, which reduces hepatic breakdown. This change in the alkylated position would be due to the fact that the 17-alpha position reduces the affinity for sex hormone binding proteins thereby decreasing the ability of the compound to free testosterone, obviously something that would make the drug far less effective for it's intended purposes. It is because of all of this that liver toxicity should be of little concern to the user running mesterolone even if it is for long periods of time, keeping in mind that other compounds still pose a threat.

The main concern with the compound is the possibility of androgenic side effects. Usually in male users these side effects will only appear if a user is administering rather large doses of the drug. An individual may encounter the typical side effects of oily skin, acne, exacerbation of male pattern baldness if the condition already exists, and body/facial hair growth. As should be expected with a compound in which dihydrotestosterone plays such a major role, prostate problems are also not uncommon with users. Women should also be aware that virilization symptoms are also a possibility with use of the compound. Deepening of the voice, menstrual irregulation, and other symptoms could all occur."

Originally posted by Bluestorm.

[deleteduser0002]

Thanks Gustovo. I've read similar articles to this claiming the same thing. But unfortunately as you mentioned clinical studies clearly stating the same thing (safe for long term use) are hard to find. Makes me wonder if its just something constantly repeated with little real data to back it up..... I'm sure that Proviron is less toxic than other oral AAS but exactly how much so I don't know.....

[gustavo77]

Thanks Gustovo. I've read similar articles to this claiming the same thing. But unfortunately as you mentioned clinical studies clearly stating the same thing (safe for long term use) are hard to find. Makes me wonder if its just something constantly repeated with little real data to back it up..... I'm sure that Proviron is less toxic than other oral AAS but exactly how much so I don't know.....

I would just get blood work done periodically, every month or two. If your liver enzymes get too high, just stop taking the Proviron and hop on some Milk Thistle or Liv52. I have seen my liver enzymes go from 74 (high) back down to 39 (normal) in one month from using milk thistle.

[faller]

The whorst thing that could happen from too much Proviron is a perpetual hard one!lol:D

I'm sold :D

[deleteduser0002]

I received a reply to this same questoin by Vegas over at MN that I thought I'd post here for those interested. This study does seem to indicate that Proviron has very low liver toxicity potential.


Int J Gynaecol Obstet. 1988 Feb;26(1):121-8.Links

The effect of mesterolone on sperm count, on serum follicle stimulating hormone, luteinizing hormone, plasma testosterone and outcome in idiopathic oligospermic men.

Varma TR, Patel RH.

Department of Obstetrics & Gynaecology, St. George's Hospital Medical School London, U.K.

Two hundred fifty subfertile men with idiopathic oligospermia (count less than 20 million/ml) were treated with mesterolone (100-150 mg/day) for 12 months. Seminal analysis were assayed 3 times and serum follicle stimulating hormone (FSH) luteinizing hormone (LH) and plasma testosterone were assayed once before treatment and repeated at 3, 6, 9 and 12 months after the initiation of treatment. One hundred ten patients (44%) had normal serum FSH, LH and plasma testosterone, 85 patients (34%) had low serum FSH, LH and low plasma testosterone. One hundred seventy-five patients (70%) had moderate oligospermia (count 5 to less than 20 million/ml) and 75 patients (30%) had severe oligospermia (count less than 5 million/ml). Seventy-five moderately oligospermic patients showed significant improvement in the sperm density, total sperm count and motility following mesterolone therapy whereas only 12% showed improvement in the severe oligospermic group. Mesterolone had no depressing effect on low or normal serum FSH and LH levels but had depressing effect on 25% if the levels were elevated. There was no significant adverse effect on testosterone levels or on liver function. One hundred fifteen (46%) pregnancies resulted following the treatment, 9 of 115 (7.8%) aborted and 2 (1.7%) had ectopic pregnancy. Mesterolone was found to be more useful in patients with a sperm count ranging between 5 and 20 million/ml. Those with severe oligospermia (count less than 5 million) do not seem to benefit from this therapy.

[faller]

Good info D-B, thanks