HGH and down regulation?

[tiramisu]

What are the impacts a HGH @ 2-4 iu's on natural production of HGH and is there an ongoing issue post treatment?

[Kiem]

If you are still under mid 30's or younger then are still producing a decent amount of natural GH, which peaks around bedtime. So avoid pinning before bedtime and use first thing in the morning. Some people use the 5on 2off method to let their system have a break and to cut cost.

If you are young and still worried about natural GH supression after cycle then the article below can be of help. Pretty much the article states that "every other day adminstration of GH gave almost exactly the same benefits as 'ever day' administration but with the added benefit that the body's sensitivity to naturally produced GH was not impacted, whereas the every day group suffered a form of inhibition or suppression if you like which took some time to recover. " But this would mean that you would still take the total amount of weeks worth of GH but split into EOD.

http://jcem.endojournals.org/cgi/content/abstract/87/8/3573

[JonnyO]

As we all know, sometimes "science" and research doesnt always speak to real world results. The studies were done on children with Idiopathic Short Stature and they dont mention the doses. Most of us dont use GH for prolonged periods of 2-4 years in length either. And from what I've gathered taking exo GH doesnt have an impact on our natural pulse we get at night. So below I highlighted in red what may indicate that ED dosing would be best for us BBers.


During hGH therapy, both groups accelerated their growth substantially, and the growth velocity was greater during the first than during the second year (Fig. 1). The first and second years’ mean growth velocities were 3.4 and 2.3 SD score for the daily therapy group and 3.0 and 2.0 SD score for the alternate day group, respectively (P = NS). Over the initial 6 months after withdrawal of therapy, growth velocity decelerated to a nadir of -3.9 SD score in the daily therapy group, whereas it decelerated in the alternate day group to only -0.2 SD score (P < 0.01). Over the entire 2 yr off therapy the latter group maintained a mean growth velocity of -0.2 to -1.2 SD score, similar to their pretreatment velocity. The daily group recovered slowly to resume their pretreatment rate only on the fourth semiannual evaluation off therapy (Fig. 1). Calculation of the cumulative 4-yr growth velocity indicated that over the entire 2-yr period on and 2-yr period off hGH therapy, the alternate day group’s growth was greater than that of the daily therapy group (mean, 0.9 vs. 0.3 SD score; P < 0.002; Fig. 2).

[Kiem]

Very interesting point Johnny.