Adex

[Baconbits]

Adex is taken either every day or every other day. I was wondering if the doseage can be spaced out even furthur...every fourth day ie: mon,thurs, sun,wed,sat.....etc...? Would this still be effective?

[Nom]

Adex has a active half life of about 3 days, IMO the strenght of this AI is usually under estimated. You can definetly space out the days in between dosages and keep it very effective.

[7 Scape O'Tech]

it has a half life of 3 days, so you should take it every day or EOD to keep blood levels steady...now that would be the case for sure if it were a stweroid, since it's not, you don't neccessarily need as steady levels of an anti-estrogen and in fact it would very from person to person based on your rate of turn over of the aromatase enzyme. So basically try it out every 3-4 days if you'd like, if you feel symptoms coming on, then begin taking it more frequent. However in this case 2mg E4D would not be the same as half mg ED.

[Baconbits]

Thanks for the replies. I'm currently on a cycle of 40mg dbol ed and 500mg test/week. I'm not sure that adex is even really needed for this cycle, but the reason for my asking is that I'm in a wedding party at the end of July and I don't want to be all bloated for the photos. At the same time I really don't wan't to sacrifice any gains at the expense of using adex. Should I just stick with nolva instead?

[monstermax]

I run my adex at .5mg 2days on one day off.

[rated_rko]

adex is good anti e

[gustavo77]

Bump 7 Scape...i take 1mg eod, works great.

[D-S]

Don't use adex or letro...use Aromasin, better for your heart...doesn't lower IGF-1, and it ussually doesn't effect your sexdrive...25mgEOD for your cycle should be good.

If ur interested Proviron or Masteron would be even better choices for an anti-e!!

[ergie]

Yup, what BBQ boy said. Letro is very potent but has many sides and usually isnt req'd, Aromasin does the same thing as adex but its a little stronger and does not affect your lipid profile nearly as much. To answer your question........ IMO most people take to much anti e's, EOD or even E3D would probably be fine but that would be dependent on your dose of course.

[gustavo77]

Don't use adex or letro...use Aromasin, better for your heart...doesn't lower IGF-1, and it ussually doesn't effect your sexdrive...25mgEOD for your cycle should be good.


I am actually swtiching over to Aromasin very soon..used it in my last pct, awesome AI and great for pct. The only thing is Aromasin has a half life of about 24 hours (you can google it..haha) and should be dosed every day.

[R.F.S.]

I have actually used Aromasin in my last cycle and it seemed to work pretty good. I wouldn't use any anti-e's unless you absolutely need to.

[D-S]

I am actually swtiching over to Aromasin very soon..used it in my last pct, awesome AI and great for pct. The only thing is Aromasin has a half life of about 24 hours (you can google it..haha) and should be dosed every day.


Yes you are correct...I have tried 12.5mgED and 25mgEOD and both worked fine for me tho...I did find 25mgED a tad to much, as I like some estrogen floatin around

[Nicknroll]

All depend on your goal bro...aromasin kill your estrogen so know that you will not have 100% benefit from your gear....but when dieting for a show aromasin is the best ai to use to stay as tight as possible but if your cycling for the gains and not bloat to much i think that .25 adex plus 25mg of proviron ed is the way to go...

[ergie]

Aromasin does not really kill your estrogen, only about 80% or so. Letro is the one that kills it thus the sides.

[Mr.Freeze]

Aromasin(exemestane) classified as a Type I suicide AI is effective at lowering estrogen up to 85%.
Femera(letrozole) classified as a competative Type II AI its effective to lower estrogen by 75-78%

[ergie]

Pretty sure letro blocks out more than that, I'll look for a study.......

[ergie]

Letrozole
(femara)

Letrozole (Femara) is the chemical name of Novartis´ selective third generationAromatase Inhibitor (AI). This drug was developed to fight breast cancer by inhibiting the aromatization. It is usually used as a part of an aggressive treatment in post-menopausal women, to fight and reverse the spread of breast cancer after other treatments (such as Tamoxifen therapy) has failed. It´s probably the most efficient product on the market for this purpose currently (5) It is very similar in structure and action to it´s predecessor Arimidex.

Letrozole (Femara) also does quite a few things which would be of interest to both bodybuilders and athletes. Firstly, it has been shown to reduce estrogen levels by 98% or greater (1). In at least one documented incidence, Letrozole (Femara) reduced estrogen in the test subject to undetectable levels, and increased LH, FSH and SHBG (4). Clearly this is all of interest to bodybuilders, as less estrogen in the body means less chance of certain side effects such as water-retention, Gynocomastia, and acne. This makes Letrozole (Femara) an appropriate choice for even the heaviest bulking or cutting cycles including harsh androgens. Also, if you are a competitive bodybuilder, Letrozole (Femara) is a must have product for contest prep; no other Ancillary compound will produce a dry and tight look like Letro will.

An effective dose of Letrozole (Femara) is .25-.5mg/day (I use .25mgs/day), but be forewarned, if you go over that amount, it can kill your sex drive. Also worth noting is that there´s a rebound effect on your estrogen when you come off Letrozol. Maximum inhibition of the aromatase enzyme has been found to happen at doses as low as 100mcg! (2)

Letrozole (Femara)´s effects on serum lipids (cholesterol, both HDL and LDL) are, in the words of one researcher: "inconsistent. " Clearly, however, you´ll eventually suffer an impaired lipid profile and immune system if you keep your estrogen levels too low for too long. Your sex drive will also probably suffer from extraordinarily low levels of estrogen present.

As previously mentioned, Letrozole (Femara) can be used to raise LH and FSH (which are hormones which signal your testes to produce more testosterone). It also, of course, will raise your testosterone levels (6) via this mechanism. Again, this is of interest to athletes and bodybuilders for obvious reasons. Letrozole (Femara), of course, can be used for post-cycle-therapy (PCT) to raise test levels, but for various reasons, Tamoxifen may be a better choice. Still, I have successfully used Letrozole (Femara) for this purpose.

How good is this compared with Aromasin and Arimidex, it´s too other main rivals? Well, In non-cellular systems, Letrozole (Femara) is 2-5 times more potent than anastrozole and exemestane in its inhibition of the aromatase enzyme and activity, and in cellular systems it is 10-20x more potent! It also lasts quite a long time in your body,but takes awhile to get going& Letrozole (Femara) has a whopping 2-4 day (!) ½ life, and you need to take Letrozole (Femara) for 60 days to get a steady blood plasma level (8).

[gustavo77]

A lot of people miss the obvious, when you are on cycle your estrogen levels are way higher than normal. When you take an AI such as Aromasin with normal hormone levels it will effective stop the production of 80% of estrogen. On cycle it will not stop 60% of your estrogen production because estrogen levels on cycle will be very high. A dose of adex, aroma or letro daily will in essence bring your estrogen levels back down to normal range...so there will still be plenty estrogen floating around to serve it's purpose.

Even though estrogen does play a small role in building muscle, i have not seen one study confirm that high estrogen levels build more muscle. IMHO, use an AI and keep the estrogen levels down and close to normal on cycle...high estrogen levels not only cause water retention and gyno but high estrogen levels increase SHBG and also excess estrogen can bind to androgen receptor blocking test from binding...this is why i always use an AI on cycle now: no bloat, no gyno, no sex drive issues and great results.

[gustavo77]

Here are some great clinical studies and findings on the three A.I.s:

Keep in mind that the % it lowers estrodiol is for normal Testosterone levels, not on cycle estrodiol levels.

1mg Arimidex ed = aprox 50% decrease in Estrogens = 58% increase in Testosterone = No change in gh = 18% decrease in IGF.

http://jcem.endojournals.org/cgi/content/abstract/85/7/2370?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=1&andorexacttitle=and&andorexacttitleabs=and&fulltext=arimidex&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT


2.5mg Letrozole ed = 46-62% lower estrogens dependent on age = 46% rise in Testosterone.

http://jcem.endojournals.org/cgi/content/abstract/90/10/5717?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=1&andorexacttitle=and&andorexacttitleabs=and&fulltext=SHBG&andorexactfulltext=and&searchid=1&FIRSTINDEX=200&sortspec=relevance&resourcetype=HWCIT


25mg Aromasin ed = aprox 40-62% lower estrogens = 60% increase in Testosterone = Plasma lipids and IGF-I concentrations were unaffected by treatment

http://jcem.endojournals.org/cgi/content/abstract/88/12/5951?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=1&andorexacttitle=and&andorexacttitleabs=and&fulltext=estrogen+male+muscle+metabolism&andorexactfulltext=and&searchid=1&FIRSTINDEX=70&sortspec=relevance&resourcetype=HWCIT

Check that out, aromasin exibited a 60% increase in testosterone in normal males. Powerful pct drug if you ask me. :)