Glutamine research

[RagingRandy]

Glutamine Research Update
Effects of an oral mixture containing glycine, glutamine and niacin on memory, GH and IGF-I secretion in middle-aged and elderly subjects.
Arwert LI. VU University Medical Center, de Boelelaan 1117, 1081 HVAmsterdam, The Netherlands.
Nutr Neurosci. 2003 Oct;6(5):269-75.
Aging is associated with declining activity of the growth hormone-insulin-like growth factor-I (GH-IGF-I) axis and with a decrease in cognitive function. The stimulatory effect of an orally administered nutritional supplement, mainly containing glycine, glutamine and niacin on the GH-IGF-I axis and on mood and cognition was investigated. Forty-two healthy subjects (14 men and 28 women, aged 40-76 years) were enrolled in a randomised, double blind, placebo-controlled trial. They received 5 g of a nutritional supplement or placebo, twice daily orally for a period of 3 weeks. At baseline and after 3 weeks, blood was collected for measurement of serum GH and IGF-I levels and mood and cognitive function were tested. The nutritional supplement ingestion for 3 weeks was found to increase serum GH levels with 70% relatively to placebo, whereas circulating IGF-I levels did not change. Mean GH increased in this group. GH increase was not associated with improvement in mood or memory. Correlation analyses, however, revealed that individual increases in IGF-I, but not GH, were associated with improved memory and vigour. It is concluded that an oral mixture of glycine, glutamine and niacin can enhance GH secretion in healthy middle-aged and elderly subjects.

[Ritch]

I hate to say this but I truely think this is one of those studies that look good on paper but just don`t transfer into real life. Remember HMB? If supplement companies really wanted to prove glutamine works they would conduct a study with bodybuilders, who eat 6x`s a day and all. I mean glutamine has been out for a long time now, yet every time I read on it the article it ends the same way "clearly more research needs to be conducted before we can come to any conclusion." Geez how long is this going to take brainiacs? Creatine has been around a little longer than glutamine and most of us can come up with a fail proof protocol. Yet We haven`t been able to do this with glutamine.

The study uses sendentary people who don`t train so obviously the results will be different. I mean 70% increase in GH as the study says is enourmous and if it worked that good real GH would not even sell in pharmacies. Or the pharmaceutical industry would try to ban it show false research that it`s harful (like they tried with ephedrine) then come out with a "better version" so they could patent it and sell it at inflated rediculous prices! Sound logical? I hope this dosen`t sound offensive but man do my eyes just roll when I hear the word glutamine...

[5151]

I hate to say this but I truely think this is one of those studies that look good on paper but just don`t transfer into real life. Remember HMB? If supplement companies really wanted to prove glutamine works they would conduct a study with bodybuilders, who eat 6x`s a day and all. I mean glutamine has been out for a long time now, yet every time I read on it the article it ends the same way "clearly more research needs to be conducted before we can come to any conclusion." Geez how long is this going to take brainiacs? Creatine has been around a little longer than glutamine and most of us can come up with a fail proof protocol. Yet We haven`t been able to do this with glutamine.

The study uses sendentary people who don`t train so obviously the results will be different. I mean 70% increase in GH as the study says is enourmous and if it worked that good real GH would not even sell in pharmacies. Or the pharmaceutical industry would try to ban it show false research that it`s harful (like they tried with ephedrine) then come out with a "better version" so they could patent it and sell it at inflated rediculous prices! Sound logical? I hope this dosen`t sound offensive but man do my eyes just roll when I hear the word glutamine...

That will be the question attached to all scientific studies until the end of time and rightfully so. The reason no studies using bodybuilders are done are because who the hell benefits? where does the money come from? and if it comes from someone who profits then the results are biased.

[Ritch]

Good post. I don`t know what to say to that other than agree. But glutamine still sucks!!!

[5151]

Good post. I don`t know what to say to that other than agree. But glutamine still sucks!!!

haha I think my post sucks and that it sucks even more it's true. Glutamine does appear to have some benefit when it comes to GI health and I've heard far more intelligent people than myself discuss different peptides however I can't really offer any worthwhile comment.

[RagingRandy]

As far as I know this is an independent study. This kind of study costs huge money and I doubt that any supplement company would pony up the dough to have it done. Even if they did, like was said previously, it would be considered biased. It is a no-win situation, so why bother.

If this study can be trusted and I suspect it can, I think Glutamine, Glycine, and Niacin are things to add into the regimen. Nothing works on its own. It is a combination of factors that determine health and size. As I am sure we can agree running a cycle with a poor diet is useless. The same goes for running a cycle and not working out. Glutamine nor any other single factor will determine whether you will reach your goals.