Receptor™

[seanf76]

http://www.lgsciences.com/images/receptor_big.gif

Do you ever wish you could go back in time when your receptors were "clean"? Why don't your second, third and fourth cycles "feel like your first time"? This is because of "dirty receptors" or better known as down-regulated androgen receptor syndrome.

Doing a cycle of steroids like Sustenon, Deca or D-Bol will make your androgen receptor down-regulate over time. Which is why your other cycles NEVER feel like " the first time". Even potent prosteroids like Superdrol, M1T and Pheraplex suffer from this same problem. LG Sciences UNLEASHES ANOTHER BOMB, by bringing you RECEPTOR, the only patent pending product that may UPREGULATE the androgen receptor and make every cycle feel like your first. If you suffer from AR down regulation syndrome, from too many cycles, clean out your receptors with the only product backed by science!

*product efficacy is dependent on proper diet and excercise

[Houstonbc]

does this actually work? what is the science behind it?

[champcar99]

http://www.lgsciences.com/images/receptor_big.gif

the only patent pending product that may UPREGULATE the androgen receptor and make every cycle feel like your first. If you suffer from AR down regulation syndrome, from too many cycles, clean out your receptors with the only product backed by science!

*product efficacy is dependent on proper diet and excercise


I always love the word "MAY" "that may "

yea ok...

[Houstonbc]

cute

[seanf76]

The androgen receptor (AR), also known as NR3C4 (nuclear receptor subfamily 3, group C, member 4), is a type of nuclear receptor which is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone. The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor.

The main function of the androgen receptor is as a DNA binding transcription factor which regulates gene expression. Androgen regulated genes are critical for the development and maintenance of the male sexual phenotype. In addition, the androgen receptor has functions independent of DNA binding.

Function

Androgenic hormones and their effect on development
In some cell types testosterone interacts directly with androgen receptors while in others testosterone is converted by 5-alpha-reductase to dihydrotestosterone, an even more potent agonist for androgen receptor activation. Testosterone appears to be the primary androgen receptor activating hormone in the Wolffian duct while dihydrotestosterone is the main androgenic hormone in the urogenital sinus, urogenital tubercle, and hair follicles Hence testosterone is primarily responsible for the development of male primary sexual characteristics while dihydrotestosterone is responsible for secondary male characteristics.

Androgens cause slow epiphysis, or maturation of the bones, but more of the potent epiphysis effect comes from the estrogen produced by aromatization of androgens. Steroid users of teen age may find that their growth had been stunted by androgen and/or estrogen excess. People with too little sex hormones can be short during puberty but end up taller as adults as in androgen insensitivity syndrome or estrogen insensitivity syndrome


Mechanism of androgen receptor action

Genomic
The primary mechanism of action for androgen receptors is direct regulation of gene transcription. The binding of an androgen to the androgen receptor results in a conformational change in the receptor which in turn causes dissociation of heat shock proteins, transport from the cytosol into the cell nucleus, and dimerization. The androgen receptor dimer binds to a specific sequence of DNA known as a hormone response element. Androgen receptors interact with other proteins in the nucleus resulting in up or down regulation of specific gene transcription. Up-regulation or activation of transcription results in increased synthesis of messenger RNA which in turn is transcribed by ribosomes to produce specific proteins. One of the known target genes of androgen receptor activation is insulin-like growth factor I (IGF-1). Thus, changes in levels of specific proteins in cells is one way that androgen receptors control cell behavior.


Non-genomic
More recently, androgen receptors have been shown to have a second mode of action. As has been also found for other steroid hormone receptors such as estrogen receptors, androgen receptors can have actions that are independent of their interactions with DNA. Androgen receptors interact with certain signal transduction proteins in the cytoplasm. Androgen binding to cytoplasmic androgen receptors can cause rapid changes in cell function independent of changes in gene transcription, such as changes in ion transport. Regulation of signal transduction pathways by cytoplasmic androgen receptors can indirectly lead to changes in gene transcription, for example, by leading to phosphorylation of other transcription factors.

One function of androgen receptor that is independent of direct binding to its target DNA sequence, is facilitated by recruitment via other DNA binding proteins. One example is serum response factor, a protein which activates several genes that cause muscle growth.