test replacement therapy question

[OldGymRat]

Hello,
I’m new here. I have a question about testosterone replacement therapy. I’ve been on 100mg of cypionate every 2nd week, via Sandoz brand 100mg /ml since last October. with and have had good results. With the recent cyp shortage I have only been able to get enanathate which is 200mg /m so I have been doing half dose.
I have not been experiencing the same results. They are sort of mixed. I feel the effects sooner after injection but it seems t run off faster, leaving me with kind of roller costar results. I have tried increasing dose as well.
My question is simply, dose the higher concentration oil release the test faster? I can’t see how 100mg or ½ mil of enanthate is the same as taking 100mg or 1 mil of cyp, since the oil is depositied to the muscle and released slowly into the blood stream. Am I right in my assumptions? Any thoughts answers, comments questions or suggestions appreciated.

[cog]

The enth is pharm?

[OldGymRat]

yes, enth and cyp are pharm, i have prescription under doctor care.

[GYMBRAT]

odd as they are soooo very close to the same prod.......

[ubcpower]

It has to be another variable in your life or you're mind ****ing yourself as its a diff ester. If ur measuring correctly and its pharm grade u should be feeling exact same thing. I bet if ulook hard enough there is some other small change in ur life: sleep, stress, workout changes, diet...etc

[OldGymRat]

thanks for the responses... wondering how much of an affect alcohol consumption has on the process?

[cog]

Plenty on your ability to recover.

[Praetorian]

Cypionate has a slightly longer half life then enanthate and a slightly heavier (1 carbon atom C8H14O2) ester than enanthate...thus you will feel the effect of enanthate sooner but it wont last as long but you are getting slightly more testosterone per 100mg/ml shot with enanthate because the ester is lighter and takes less space in that 100mg. In a 1ml shot of 100mg testosterone enanthate 45% of the gross weight is actually the enathate ester not active testosterone which is 55mg. In test prop the lighter ester (26%) yields 74mg testosterone in 100mg. Also because of the ester the active half life of cyp is slightly longer so if using enanthate I would suggest reducing the duration between shots from two weeks to say 10-12 days.

[OldGymRat]

Thanks for the responses, from the research I have done I understand what you are saying. My original post was more about the concentration of the two I have used and was wondering if my theory is correct. From what I understand enanthate or cyp is suspended in oil which is injected into the muscle. The oil is slowly released into the bloodstream where the ester is removed, and the test is free to do its thing. I assume the oil in each is absorbed to the blood stream at the same rate. So even if I am injecting say 100 mg the enth is 200 mg / mil, so I inject ½ that of the cyp, 100mg / mil. So in the time I absorb .5 mil I am getting double the test in the same time period. Am I right? Or is the oil straight to the blood stream all at once. My reason is the enanthate gives me more of a rollercoaster of symtoms or low test. It is the only test I can get right now and have been complaining to the doc, but he says there is no diff.

Cheers,

[Praetorian]

Regarding the strength of solution...the Cypionate ester is heavier thus takes up more space and thus you get less testosterone in the same 1 ml injection as compared to enanthate. When you inject the solution the ester is cleaved allowing the test to attach to androgen receptors...the oil is just a carrier. You may feel more or a roller coaster with the enanthate because the half life is shorter and the solution is stronger...by reducing the amount say to .8ml and shortening the time between injection to 12 days instead of 14 you may be able to mimick the cypionate.
P

[OldGymRat]

praetorian, thanks againfor taking the time to answer. I am new to all this, but will continue to learn, and share my experience when ever I can.

cheers

[OldGymRat]

oh, one more ask if I may. I'm 46 and my doc says I will be doing this therapy for the rest of my life to remain with a normal sex drive. Should i be thiking about an anti est, or AI? I ask because during my "low" period I tend to feel a sensativity around the nipples. Gyno type symtoms. I dnt think I look Gyno'ish ..... yet. Any thoughts appreciated.

[Praetorian]

At a trt dosage most would not require an AI...there is little conversion...but it is individualistic. I could also cause libido issue by driving estrogen too low.
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[ubcpower]

Prae why are all these hrt guys who get scripts from clinics almost always given an ai when they're looking to get their test in the normal range with say 100mg/week of test? Doesn't make sense to me as you don't see regular person with test levels in the normal range being prescribed an ai? Does it have something to do with an undesired aromatizing response by those on trt to the synthetic testosterone

[zziggzzigg]

Prae why are all these hrt guys who get scripts from clinics almost always given an ai when they're looking to get their test in the normal range with say 100mg/week of test? Doesn't make sense to me as you don't see regular person with test levels in the normal range being prescribed an ai? Does it have something to do with an undesired aromatizing response by those on trt to the synthetic testosterone

good question, I think maybe the pulsatile dosing of natural test secretions are maybe less likely to aromatize compared to injections or gels, as the injections or gels are not as good as a perfectly functioning normal endocrine system at microdosing throughout the day and week

[RagingRandy]

I am on HRT and found weekly injections of either Eth or Cyp work best for me. I do not use any AI.

[Praetorian]

Prae why are all these hrt guys who get scripts from clinics almost always given an ai when they're looking to get their test in the normal range with say 100mg/week of test? Doesn't make sense to me as you don't see regular person with test levels in the normal range being prescribed an ai? Does it have something to do with an undesired aromatizing response by those on trt to the synthetic testosterone

Not sure the specific reason behind that...there is very little conversion to estrogen at that dosage and taking an AI can have negative effects on libido not to mention lipid profile and liver enzymes. It is very individualistic as I have seen some have estro issues on a TRT dose but most do not. I would error on the safe said and see what happens first without an AI.
P