Igf-lr3

[#8]

Does this peptide pose the same risks associated with dosing actual IGF-1? Is IGF-1 the same as insulin? Is it as dangerous as insulin? Ive read a ton about these things and Im still confused as to how bad it is and what doses a newb is supposed to run it at?

[Praetorian]

The risk is relatively small...mostly because it becomes ineffective over time. It is not the same as insulin it is a completely different hormone. Insulin does not cause hyperplasia. No it is not as dangerous as insulin as it does not cause hypoglycemia to the degree insulin does. 10-20 mcg daily 4 weeks on 2 weeks off is sufficient for muscle growth...it does seem to work much better in combination with gh....and you should also be running a decent dose of test.
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[#8]

is it used immediately post workout in conjunction with a high carb protein shake? when is it taken on off days (if at all)?

[Praetorian]

is it used immediately post workout in conjunction with a high carb protein shake? when is it taken on off days (if at all)?

Best taken 10mcg in the morning with breakfast and 10mcg post workout with your shake...on days off 10mcg in the morning is fine.
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[bcaamuscle]

What sort of side effects could be expected with this compound? I've heard of people getting diarrea

[Praetorian]

Never heard of diarrhea...either it wasn't IGF-1LR3 or it was coincidental. Possible sides could include growth of extremities ie hands, feet etc...these areas contain more IGF receptors..this is the theory but I've never seen or heard of it.
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[#8]

Its just a sub q shot in the stomach like GH right? Can you mix it in the same pin as your GH if running it at the same time?

[Praetorian]

Intra muscular and no do not mix them.
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[#8]

I read on ology that some guys have gotten guts from shooting this stuff, im assuming that was from subq shots in the stomach and the resulting hyperplasia. Do IM shots need to be shot into the muscles trained (ie, delts on shoulder day, bi's on arm day, quads on leg day etc)? Or can One get away with just shooting delts and glutes and it end up having the same effect all over the body?

[Praetorian]

What you read is complete BS...you dont get distended stomach from IGF...even if you didnt train and the IGF went to the highest concentration of IGF receptors in the body that would the extremities...not the gut. Distended stomach comes from the massive quantities of food required to grow...mostly you see this on Superheavy guys only. IM shots can be in the delts...there is no need to shoot into the muscle trained etc...with LR3 that is a myth...it becomes systemic within minutes...hence the reason it was designed as LR3.
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[#8]

Can I just say again that you are basically the ****in MAN! Seriously, you are without a doubt one of if not the most valued members here. As soon as I am out of debt I will absolutely contract your services.

Thank you

[Praetorian]

Thank you...glad to help.
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[#8]

I just read in another thread you posted in a couple years back that only IGF1 and NOT LR3 causes hyperplasia. Is the LR3 basically just a GDA then? Can one expect to keep any of the gains attained from an LR3 cycle?

[Praetorian]

Ive tried LR3 many times on it own with little to no results...only once i started using it combined with GH did i notice significant effects...hence my post. This may be individualistic but ive noticed it in some of my clients as well...it is a great GDA however yes.
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[#8]

I will be running a dose of 2iu a day of GH for many weeks in the near future to help with my sleeps and recovery. I was thinking about stacking it with the LR3 for better recovery. Is this enough of a GH dose to notice effects as you mentioned?

[bigtavi8]

stupid question of the year but how do you shoot such a small amount (10mcg) IM. Seriously please dont flame me im being honest. Do you just use a half inch slin pin and go straight on (90 deg) into the delt and hope ur lean enough? How would you dose 10mcg in a regular 3ml syringe to do a IM shot.

[#8]

^^ good question. not dumb at all. was also wondering that

[bigtavi8]

THANK GOD #8 lol i was worried about asking that but its been on my mind. I may have some sitting at home :)

[Praetorian]

I will be running a dose of 2iu a day of GH for many weeks in the near future to help with my sleeps and recovery. I was thinking about stacking it with the LR3 for better recovery. Is this enough of a GH dose to notice effects as you mentioned?

That amount of gh will be fine...recovery possibly but dont expect large gains in size.
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[Praetorian]

stupid question of the year but how do you shoot such a small amount (10mcg) IM. Seriously please dont flame me im being honest. Do you just use a half inch slin pin and go straight on (90 deg) into the delt and hope ur lean enough? How would you dose 10mcg in a regular 3ml syringe to do a IM shot.

10mcg is the amount of IGF-1LR3 this measurement has nothing to do with volume. If you get IGF-1LR3 in small vials usually each contain 100mcg...add 1ml of mixing solution ie BS water or acetic acid solution to the vial and use a slin pin...10 ticks on the slin pin is 10mcg...inject in the delt as long as you are not obese youll be fine.
P

Here is how to dose, mix etc if it all come sin a single vial.

By DP


(1)-STORAGE OF IGF-1(prior to mixing)
lyophilized (dry) IGF-1is stable at room temperture for three weeks;however,it should be stored below -18 degrees celsius (in the freezer section).

(2)WEIGHT OF IGF-1
1 milligram (mg) IGF-1 = 1,000 mcg (micrograms) IGF-1 (dry weight- before mixing).

(3) WHAT TO MIX THE IGF-1 WITH
when reconstituting,its important to remember IGF-1 can get "stuck" in the grooves of the glass bottle it comes packaged in. while glass appears smooth to the naked eye, under a microscope, it's a convoluted landscape of grooves and hidden recesses.
By mixing the lyophilized IGF-1 with an "acid water" (e.g., 10mM HCL -very dilute hydochloric acid), the IGF-1 molecules are efficiently detached from the glass and solubilized in the mixture. Any online "compounding" laboratory could mix up a 10mM HCL solution. likewise, any intro chemistry student should be able to do the same.
If a reliable source of "acid water" can't be located, mix your IGF-1 powder with BACTERIOSTATIC WATER - you'll lose, at worst, 10 percent of the IGF-1 solution.

(4) ADDING THE ACID WATER
For the purposes of mathematical ease, I suggest mixing the dry 1 milligram (1,000 microgram) IGF-1 with 3ml (or 3cc) of the "acid water" mixture.

(5) PRESERVATION OF THE IGF-1
Next,using a 1cc insulin syringe,draw out 1cc out of the bottle containing the 3cc acid water/IGF-1 mixture.In a seperate 1cc insulin syringe,draw up another 1cc of the solution.Freeze these two loaded insulin syringes.They will be utilized at a later date.

NOTE:Freezing can safely and effectively preserve IGF-1(even after its been mixed)

(6)THE CORRECT DILUTION
To the remaining 1cc of IGF-1 thats left in the glass bottle,add 2cc of bacteriostatic water.This will return the total volume back up to 3cc.

(7)THE MATHEMATICS
(A)The original concentration of the IGF-1 solution was 1mg(1000 micrograms)
IGF-1 in 3cc of water.

(B)Each 1cc that was removed,then,contained approximately 333 micrograms IGF-1 per 1cc.

1,000 micrograms/3cc = 333 micrograms per 1cc

©The 1cc that was left in the bottle,then,also contains 333 micrograms of IGF-1.

(D)Next,we added 2cc of bacteriostatic water to the bottle and brought the volume back up to 3cc.The difference is we now have 333 micrograms in 3cc of water (instead of in 1cc)

(E)To determine how much IGF-1 is in 1cc,you must divide by three.

333 micrograms/3cc=111 micrograms per 1cc

(F)To determine how much IGF-1 is in .10cc (or 1/10thcc) we do the following.

111 micrograms/10=11micrograms per .10cc

(8)EFFICTIVE DOSAGES OF IGF-1
Dosages in the range of 10 to 20 micrograms per day(taken 10 to 15 minuters after training) are quite effective for building and repairing muscle tissue.
More importantly,these moderate dosages (by some peoples estimation)
stimulate muscle growth yet escape rapid "downregulation" of the all important IGF-1 receptors.
Without receptors to recognize the IGF-1,it doesnt matter how much you inject.
NOTHING will happen.
As dosages climb to over 50 micrograms per day,receptor downgrade increases exponentially and,from what I've observed among bodybuilders,muscle gains come to a screeching hault.

Bodybuilders will have the most sucess with IGF-1 if they follow the protocol I outlined below. REMEMBER, more isn't always better.

11 micrograms per day for 30 days (cycle 1) 333 micrograms

2 weeks OFF

11 micrograms per day for 30 days (cycle 2)** 333 micrograms

2 weeks OFF

11 micrograms per day for 30 days (cycle 3)** 333 micrograms

8 weeks OFF


** The second and third cycles of IGF-1 treatment require that the two Frozen 1cc insulin syringes be defrosted(only defrost one per cycle).
Next,inject the defrosted solution into an empty bottle.
Further dilute with 2cc bacteriostatic water. When adding the 2cc of water,use the syringe that originally held the frozen IGF-1.
This also helps to wash the syringe and ensure that no IGF-1 is stuck inside of it.

[bigtavi8]

Apparently i can not rep u P but thanks a lot ive been looking for this info for a while. Thanks for everything.

[ironwill]

That's the article i found to mix and store and use as well....It friggin works well, as P said with GH......I follow that to a T, and love the effects....Its even useful with gh, during PCT, stayed more full and i think better recovery..4 Thumbs up!!!

[#8]

In that article DP recommends running 11mcg a day for the duration of the cycle. Is that 11mcg only or 11mcg per shot? Can I get away with running 11mcg for those 4 weeks on and still see decent results?

Im not looking for magic here, but a little boost wouldnt hurt. My training and diet are good, I just want something to help speed up my recovery and such.

[Praetorian]

In that article DP recommends running 11mcg a day for the duration of the cycle. Is that 11mcg only or 11mcg per shot? Can I get away with running 11mcg for those 4 weeks on and still see decent results?

Im not looking for magic here, but a little boost wouldnt hurt. My training and diet are good, I just want something to help speed up my recovery and such.

Thats 11mcg per day...and yes you would be fine at that dosage.
P

[juced_porkchop]

What you read is complete BS...you dont get distended stomach from IGF...even if you didnt train and the IGF went to the highest concentration of IGF receptors in the body that would the extremities...not the gut. Distended stomach comes from the massive quantities of food required to grow...mostly you see this on Superheavy guys only. IM shots can be in the delts...there is no need to shoot into the muscle trained etc...with LR3 that is a myth...it becomes systemic within minutes...hence the reason it was designed as LR3.
P
I agree with all this but goign IM. just go subQ it will be flowing in minuts. and is less hassle and less scar tissue then pinning IM. ill save IM for my aas.

[Praetorian]

IGF IM is simple and easy using a slin pin...same as subq no scar tissue either.
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[JonnyO]

Dont waste your $ on IGF bro, spend it on HGH instead if your going to. Maybe Ive had the bad luck of getting poor or low quality stuff, but all I really got off it was a pump, and even that was with one kind I had. It could also be person specific as well because some report pretty good gains from it, but thats just not in my case. I think GH on the long run would be a lot more beneficial for you and what you are looking to get out of it--->better sleep + recovery.

[Praetorian]

Dont waste your $ on IGF bro, spend it on HGH instead if your going to. Maybe Ive had the bad luck of getting poor or low quality stuff, but all I really got off it was a pump, and even that was with one kind I had. It could also be person specific as well because some report pretty good gains from it, but thats just not in my case. I think GH on the long run would be a lot more beneficial for you and what you are looking to get out of it--->better sleep + recovery.

I noticed the same thing JO...only once i started running it with GH did i see any difference.
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[JonnyO]

I noticed the same thing JO...only once i started running it with GH did i see any difference.
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Well I am not one to discredit something unless Ive tried it on all accounts...this I might have to give a go then and see.

[ironwill]

I certainly believe it should be run with gh, as laid out....Ive ran on its own with not noticing to much, but with gh i really noticed a big difference....

[juced_porkchop]

The risk is relatively small...mostly because it becomes ineffective over time. It is not the same as insulin it is a completely different hormone. Insulin does not cause hyperplasia. No it is not as dangerous as insulin as it does not cause hypoglycemia to the degree insulin does. 10-20 mcg daily 4 weeks on 2 weeks off is sufficient for muscle growth...it does seem to work much better in combination with gh....and you should also be running a decent dose of test.
P

WOW thats small and short I feel i had much better results with 50-70mcg ed for 6-10wks. (with igf-1LR3)
before or post WO se

[juced_porkchop]

is it used immediately post workout in conjunction with a high carb protein shake? when is it taken on off days (if at all)?

this gets debated all the time. but igf1lr3 will have a half life of about 20-30hrs so more then one shot per day is not needed.
I have used it preWO and Post. PreWO you get a bit more of a pump while working out. but now i use it at night alogn with MT2 right now and still havign very nice results. (at 50mcg ed) just finished my 10wk run yesterday acually lol.

[juced_porkchop]

Never heard of diarrhea...either it wasn't IGF-1LR3 or it was coincidental. Possible sides could include growth of extremities ie hands, feet etc...these areas contain more IGF receptors..this is the theory but I've never seen or heard of it.
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i agree, never herd of dairrhea from it. also agree about theory. im sure in some years we will prob know for sure.

[juced_porkchop]

Its just a sub q shot in the stomach like GH right? Can you mix it in the same pin as your GH if running it at the same time?

I go subQ with igf-1lr3 for all my runs with it and it works great . ill save up on uneeded scar tissue fr my aas. also it gos systemic in minuts so it raly dont matter in my op, the effects will be the same in the end. atleast from my exp .

[juced_porkchop]

I just read in another thread you posted in a couple years back that only IGF1 and NOT LR3 causes hyperplasia. Is the LR3 basically just a GDA then? Can one expect to keep any of the gains attained from an LR3 cycle?

i onkly use the lr3. the onyl diff is instead of having a abotu a 10minut half life liek igf1 the igf1lr3 has an extended life of about 20hrs.
think testp to teste ??

[juced_porkchop]

Praetorian I am VERY sorry I just noticed this was your section. shit man im very sorry if i offended you posting here. my bad.
i was wondering why no one else was chiming in.
sorry man.

[#8]

Does LR3 result in receptor downregulation or lack of ability to absorb it effectively? Not sure if im expressing my question properly but I think you know what I mean....

[Praetorian]

WOW thats small and short I feel i had much better results with 50-70mcg ed for 6-10wks. (with igf-1LR3)
before or post WO se

Using that dosage will work for short period of time...receptor downgrade is vary quick at that dose and after a a week or two most is just being wasted.
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[Praetorian]

Does LR3 result in receptor downregulation or lack of ability to absorb it effectively? Not sure if im expressing my question properly but I think you know what I mean....

Yes is does and it is dose dependant....above the 10-20mcg daily receptor downgrade occurs quite rapidly.
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[#8]

I know that you advocate the 4 weeks on and 4 weeks off method, but does this method avoid IGF receptor degredation? Can it be run potentially this way indefinitely? I suppose there are no long term studies that have been conducted on these peptides, but to the best of your knowledge is 4 on 4 off ok to run for up to a year or more?

[Praetorian]

Its 4 on 2 off, 4 on 2 off, and 4 on then at least 8 off...yes it is to combat receptor downgrade....over time IGF just stops working if you run it indefinitely so you would just be wasting money.
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[#8]

ah ok. thanks.

[ironwill]

I run it 4 on 2 off, and it works well........In my opinion also.....

[A_N_T]

Hi Praetorian! is it true that if use just BACTERIOSTATIC WATER to dissolve igf it will be wasted in 24 hours? and u have to use acid water?

[Praetorian]

Not at all...you might lose a bi of potency...10% at most but thats all...it will still be stable to use for a week or more.
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[Praetorian]

Store the vial you are using in the fridge..its good for at least 4 weeks. Store the others in the freezer they are good for a few months.
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[Steeve1000]

what about peptides like ghrp6 with igf1lr3

[Praetorian]

When reconstituted they should be refrigerated...even if not reconstituted when storing I would still keep them in the fridge.
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[Steeve1000]

what do you think of ghrp6 and igf1lr3 combos ? i heard that some persons use it during pct to maintain gain

[Praetorian]

IGF Lr3 and HGH yes...as for the other peptides I would say its a gamble at best.
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[#8]

Because I drink my protein / carb shake during my workout because Im dieting fairly low carb, should I be taking my LR3 shot before my workout, then head to the gym and down my shake as I train? Will the timing of the shot be important compared to when I drink my high carb shake?

I tend to wait around 60-90 minutes after my intra workout shake to eat a whole food meal of meat and veggies. Should I shoot the LR3 before the workout or after, seeing as I dont eat after my workout for about 90mins sometimes?

[Praetorian]

Post workout is better...have it before you eat your whole food meal.
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[L3]

from my experience both in ketosis or not, pinning 11mcg of IGFLR3 immediately pwo (as in the bathroom stall) keeps your muscles full for the next 4-6 hrs...it is f-in unreal

[#8]

Post workout is better...have it before you eat your whole food meal.
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how soon before?

[Praetorian]

A few minutes...doesnt make a whole lot of difference...also if you are dieting I wouldnt have a shake during your training...you are just slowing fat loss.
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[#8]

I find it hard to have energy during the workout without having carbs during. I have probably reduced my carbs too quickly. Thanks for the advice.

[luvs2lift]

does insulin help with downregulation of receptors? Thought i read that somewhere..

[Praetorian]

does insulin help with downregulation of receptors? Thought i read that somewhere..

Its the other way around...IGF-1 supposedly helps up regulate insulin receptors...ie improves insulin resistance which can occur from long term GH use.
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