HGH and IGF-1

[yannyboy]

Prae can you clear up a problem I have with these 2 peptides.
I know that HGH gets converted to IGF-1 by the liver and this is the part which is responsible for muscle growth. So why are we told when taking IGF-1 that you should limit the dosage and cycle it for about 4 weeks to avoid receptor shutdown but with HGH you should try to stay on as long as possible to see noticible results.
Cheers.

[juced_porkchop]

Prae can you clear up a problem I have with these 2 peptides.
I know that HGH gets converted to IGF-1 by the liver and this is the part which is responsible for muscle growth. So why are we told when taking IGF-1 that you should limit the dosage and cycle it for about 4 weeks to avoid receptor shutdown but with HGH you should try to stay on as long as possible to see noticible results.
Cheers.
Its not because of shut down its sides and the unknown. igf1-lr3 has not been around for aslong as HGH and alot of weird info on it out there I have seen.
I personally run it for 6-8weeks at 50-70mcg ed.
its much better then HGH and you see more results for less cost to top it off.
I HIGHLY rec igf-1lr3

[Praetorian]

Prae can you clear up a problem I have with these 2 peptides.
I know that HGH gets converted to IGF-1 by the liver and this is the part which is responsible for muscle growth. So why are we told when taking IGF-1 that you should limit the dosage and cycle it for about 4 weeks to avoid receptor shutdown but with HGH you should try to stay on as long as possible to see noticible results.
Cheers.


Well a couple things....GH is NOT converted to IGF in the liver....it mediates IGF-1 production via the liver...as well the IGF-1 produced by the liver is not LR3...thus it does not last as long in the body and 99% is bound to specific binding proteins...only 1% actually exerts any hyperplasia effects. Exogenous IGF-1 itself has been around for a long time...but it is very expensive and very unstable. IGF-1 LR3 is relatively new in comparison and was designed to avoid being bound (added chemically bound side chains) and lasts longer in the body approx 12 hours as opposed to 20 min. Injecting IGF-LR3 following a workout allows the IGF-1 to circulate and locate newly produced IGF-1 receptors on the damaged muscle cell membranes. These new receptors appear as a direct result of damage induced by intense weight training and muscular trauma. It is at these damaged cells that the body increases the number of IGF-1 recpetors so it can signal where the muscle repairs must be performed. This is why muscle cells grow, preferentially, and not bone tissue or internal organs, as rumoured.
However, as the dosage of IGF-1 increases above 10-20mcg per day, the IGF-1 muscle cell receptors become saturated and now all this excess IGF-1 goes straight to the highest naturally occuring concentration of IGF-1 receptors - the extremities (i.e feet, hands and facial bones). Additionally, high Long R3 IGF-1 dosing will lead to decreases in muscle cell IGF-1 receptors, thus diminishing the results seen with Long R3 IGF-1 usage over time. Empirical evidence has shown that 10-20mcg per day of Long R3 IGF-1 causes significant muscle cell hyperplasia and will continue to do so extremely effectively for approximately 30 days. Even with a conservative dosage IGF-1LR3 will stop working after a period of time...its best to take some time off ie 2-4 weeks after 30 days of use.
Thus taking GH mediates IGF-1 in the liver but only a very small amount and 99% is bound and doesnt last long...thus the need for taking it for a longer duration.
P

[yannyboy]

Cheers Prae.
So are you saying that because HGH stimulates IGF-1 rather than IGF-LR3, it can be used constantly for a longer period of time?

[Praetorian]

The liver produces IGF-1 not IGF-1LR3 via HGH...LR3 has been chemically altered artificially to allow it to last longer by not binding to specific binding proteins...so in essence yes HGH needs to be used longer for maximum effect.
P

[yannyboy]

One last question Prae, for bulking cycles, will IGF-LR3 be a better addition than HGH?