juced_porkchop
08-12-2010, 06:57 PM
Some info:
We are releasing a new product called Rezolution on 1.1.11
It's a happy pill that burns fat and gets you amped unlike anything
you've ever experienced!
What Rezolution does?
Combines the most potent stimulants (specialized synephrine, geranamine,
caffeine) with dopamine precursors (N-Actyl Tyrosine and L-Dopa) plus
two herbs that block both Dopamine and Norepinephrine re-uptake (meaning
makes dopamine active longer). Add in 5-HTP for increased serotonin and
you get a natural high and a stimulant effect that lasts for hours.
Sweet spot is 3 capsules (for experienced users)
The two ingredients that make dopamine active longer are:
Dopamine transporter inhibitory and antiparkinsonian effect of common
flowering quince extract.
Zhao G, Jiang ZH, Zheng XW, Zang SY, Guo LH.
Common flowering quince (FQ) is the fruit of Chaenomeles speciosa
(Sweet) Nakai. FQ-containing cocktails have been applied to the
treatment of neuralgia, migraine, and depression in traditional Chinese
medicine. The present study assessed whether FQ is effective in dopamine
transporter (DAT) regulation and antiparkinsonism by utilizing in vitro
and in vivo assays, respectively. FQ at concentrations of 1-1000
microg/ml concentration-dependently inhibited dopamine uptake by Chinese
hamster ovary (CHO) cells stably expressing DAT (D8 cells) and by
synaptosomes. FQ had a slight inhibitory action on norepinephrine uptake
by CHO cells expressing the norepinephrine transporter and no inhibitory
effect on gamma-aminobutyric acid (GABA) uptake by CHO cells expressing
GABA transporter-1 or serotonin uptake by the serotonin transporter. A
viability assay showed that FQ mitigated
1-methyl-4-phenylpyridinium-induced toxicity in D8 cells. Furthermore,
in behavioral studies, FQ alleviated rotational behavior in
6-hydroxydopamine-treated rats and improved deficits in endurance
performance in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
(MPTP)-treated mice. Furthermore, immunohistochemistry revealed that FQ
markedly reduced the loss of tyrosine hydroxylase-positive neurons in
the substantia nigra in MPTP-treated mice. In summary, FQ is a
selective, potent DAT inhibitor and has antiparkinsonian-like effects
that are mediated possibly by DAT suppression. FQ has the potential to
be further developed for Parkinson's disease treatment.
Inhibitive effects of Fructus Psoraleae extract on dopamine transporter
and noradrenaline transporter.
Zhao G, Li S, Qin GW, Fei J, Guo LH.
A petroleum ether extract (FP) from Fructus Psoraleae, seeds of Psoralea
corylifolia L. (Leguminosae), was found to strongly inhibit dopamine
(DA) uptake by dopamine transporter (DAT) heterogeneously expressed
cells (D8 cells) and noradrenaline (NE) uptake by noradrenaline
transporter (NET) heterogeneously expressed cells, which, however, had
no effect on gamma-aminobutyric acid transporter heterogeneously
expressed cells and serotonin transporter heterogeneously expressed
cells at the concentration up to 100 microg/ml. These inhibitory effects
were also confirmed by experiments on SK-N-SH cell line and synaptosomes
from rats' brains. In addition, FP showed a significantly mitigating
effect on 1-methyl-4-pyridinium induced injury of D8 cells. Meanwhile,
FP dose-dependently reduced the binding of tritium-labeled cocaine
analog (-)-2beta-carbomethoxy-3beta-(4-fluorophenyl) tropane to DAT of
D8 cells, which suggests that FP may inhibit DAT activity in the same
way as cocaine does. Behavioral study showed FP had a long-lasting
stimulant effects on the activity of intact mice and reserpinized mice.
So FP is proposed as a kind of DAT and NET inhibitor and may be involved
in the process of regulating the DA and NE system, and FP or its unknown
bioactive compounds may be developed into new medicines for disorders
such as Parkinson's disease, depression, Attention Deficit Hyperactivity
Disorder (ADHD) or cocaine addiction.
Keep an eye out guys at lgsciences.com :-D
Im very excited to try this out myself in spring!
We are releasing a new product called Rezolution on 1.1.11
It's a happy pill that burns fat and gets you amped unlike anything
you've ever experienced!
What Rezolution does?
Combines the most potent stimulants (specialized synephrine, geranamine,
caffeine) with dopamine precursors (N-Actyl Tyrosine and L-Dopa) plus
two herbs that block both Dopamine and Norepinephrine re-uptake (meaning
makes dopamine active longer). Add in 5-HTP for increased serotonin and
you get a natural high and a stimulant effect that lasts for hours.
Sweet spot is 3 capsules (for experienced users)
The two ingredients that make dopamine active longer are:
Dopamine transporter inhibitory and antiparkinsonian effect of common
flowering quince extract.
Zhao G, Jiang ZH, Zheng XW, Zang SY, Guo LH.
Common flowering quince (FQ) is the fruit of Chaenomeles speciosa
(Sweet) Nakai. FQ-containing cocktails have been applied to the
treatment of neuralgia, migraine, and depression in traditional Chinese
medicine. The present study assessed whether FQ is effective in dopamine
transporter (DAT) regulation and antiparkinsonism by utilizing in vitro
and in vivo assays, respectively. FQ at concentrations of 1-1000
microg/ml concentration-dependently inhibited dopamine uptake by Chinese
hamster ovary (CHO) cells stably expressing DAT (D8 cells) and by
synaptosomes. FQ had a slight inhibitory action on norepinephrine uptake
by CHO cells expressing the norepinephrine transporter and no inhibitory
effect on gamma-aminobutyric acid (GABA) uptake by CHO cells expressing
GABA transporter-1 or serotonin uptake by the serotonin transporter. A
viability assay showed that FQ mitigated
1-methyl-4-phenylpyridinium-induced toxicity in D8 cells. Furthermore,
in behavioral studies, FQ alleviated rotational behavior in
6-hydroxydopamine-treated rats and improved deficits in endurance
performance in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
(MPTP)-treated mice. Furthermore, immunohistochemistry revealed that FQ
markedly reduced the loss of tyrosine hydroxylase-positive neurons in
the substantia nigra in MPTP-treated mice. In summary, FQ is a
selective, potent DAT inhibitor and has antiparkinsonian-like effects
that are mediated possibly by DAT suppression. FQ has the potential to
be further developed for Parkinson's disease treatment.
Inhibitive effects of Fructus Psoraleae extract on dopamine transporter
and noradrenaline transporter.
Zhao G, Li S, Qin GW, Fei J, Guo LH.
A petroleum ether extract (FP) from Fructus Psoraleae, seeds of Psoralea
corylifolia L. (Leguminosae), was found to strongly inhibit dopamine
(DA) uptake by dopamine transporter (DAT) heterogeneously expressed
cells (D8 cells) and noradrenaline (NE) uptake by noradrenaline
transporter (NET) heterogeneously expressed cells, which, however, had
no effect on gamma-aminobutyric acid transporter heterogeneously
expressed cells and serotonin transporter heterogeneously expressed
cells at the concentration up to 100 microg/ml. These inhibitory effects
were also confirmed by experiments on SK-N-SH cell line and synaptosomes
from rats' brains. In addition, FP showed a significantly mitigating
effect on 1-methyl-4-pyridinium induced injury of D8 cells. Meanwhile,
FP dose-dependently reduced the binding of tritium-labeled cocaine
analog (-)-2beta-carbomethoxy-3beta-(4-fluorophenyl) tropane to DAT of
D8 cells, which suggests that FP may inhibit DAT activity in the same
way as cocaine does. Behavioral study showed FP had a long-lasting
stimulant effects on the activity of intact mice and reserpinized mice.
So FP is proposed as a kind of DAT and NET inhibitor and may be involved
in the process of regulating the DA and NE system, and FP or its unknown
bioactive compounds may be developed into new medicines for disorders
such as Parkinson's disease, depression, Attention Deficit Hyperactivity
Disorder (ADHD) or cocaine addiction.
Keep an eye out guys at lgsciences.com :-D
Im very excited to try this out myself in spring!