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Canadian Bodybuilding
23-04-2008, 01:40 AM
JUDITH TIMSON

From Tuesday's Globe and Mail

April 22, 2008 at 8:47 AM EDT

One of my closest friends calls me occasionally at about 6 p.m. and jokes, "Is it time yet?" I know exactly what she's talking about. We've both been working our rear ends off and she wants to know if I'm as ready as she is for an end of day glass of wine.

That glass of wine is symbolic - the start of evening and a so-called personal life. And palliative - so soothing after a day of frustrating work, traffic tie-ups, soul weariness. It's a reward for making it through another day, as well as a dollop of sophistication amid domestic duty - the Sisyphean task of cooking the evening meal or getting the kids to bed.

Yet that one glass of wine - the pleasure of it, the taste of it and, most of all, the beloved ritual of it - is now under siege. The release last week of startling research on the link between drinking alcohol and getting breast cancer has sparked new fears in many women.

According to the study conducted by the U.S. National Cancer Institute, the headlines blared, women who consumed less than one drink a day had a 7-per-cent increase in their risk of developing certain very common estrogen-fuelled breast cancers.

Take one or two drinks a day and your chances of getting these tumours increase 32 per cent, and three or more drinks boosts your risk 51 per cent.

Now, I am able to block out all sorts of dire health warnings - possibly because I'm relatively healthy, diligently downing my steel-cut oatmeal in the morning and my broccoli at night - but this one was unsettling. If you believe the statistics, what comes through loud and clear is that basically no alcohol is best for women, especially postmenopause.

In fact, alcohol could be the new nicotine for women - with black and white warnings on every bottle of pinot grigio soon to come, announcing drinking alcohol may lead to breast cancer.

Yet unlike with cigarettes, this feels like an assault on our lifestyle.

If I am honestly totalling up what I imbibe, I can get to six or seven drinks a week pretty quickly: one small glass of wine on many nights, with a second glass at dinner on the weekends. I haven't been drunk in years. I am not known in my social universe as an eyebrow-raising drinker.

Yet I now feel like a shiraz-fuelled ticking cancerous time bomb.

It isn't fair. Whatever happened to the "red wine is good for your heart" story? Can we not bring this back? In fact, we can, but researchers made it clear it's a matter of naming your poison. If breast cancer is in your family history, then reducing alcohol would be a good idea. If there's no breast cancer but there is heart disease, keep drinking - moderately. And if there's both? No fun there - just take a brisk walk and eat more veggies. No alcohol for you.

What a bore. I feel as though the last bastion of civilization is about to fall. I grew up watching my mother enjoying her glass of sherry before dinner. It's what adults did. She eventually switched to wine and religiously adhered to her (one) cocktail until she died at 90, with no sign of breast cancer.

Although when I was growing up, no one served wine with dinner, we're a wine-drinking society now. One predinner drink just leads to more wine around the table.

The new findings also make me concerned for the twentysomething generation of female drinkers. Go on Facebook and look at your daughters, most of them with glasses in hand and goofy grins on their faces.

Of course, I could be called a hypocrite for monitoring my children's alcohol intake while craving a nightly drink myself.

Juergen Rehm, a senior scientist at the Centre for Addiction and Mental Health and professor of psychiatry at the University of Toronto, was slightly reassuring on the subject.

While he doesn't like to give direct advice, he said in a telephone interview, in general, "because the risk is only slightly elevated, if it's really one glass a day, frankly, I would not care. Life is risky anyway."

However, if it's more than that, Dr. Rehm said, everyone would do well to cut back. The other problem, he added, is that most of us underestimate how much we really do drink.

I was just about to get off the phone when he added cheerfully: "There's one more thing to consider." Of all the life risks we knowingly assume, Dr. Rehm said - such as living in homes with radon, driving on highways or drinking water with questionable chemicals in it - "no other risk is as high or as unregulated as the risk we assume drinking alcohol over our lifetime."

That took my breath away. I'm definitely cutting back, I told my friend, I'll make mine mineral water with a twist of lemon. "Me, too," she said.

Two days later, we were back on the phone: "I started thinking about those warmer nights and sitting on the patio with a ... glass of wine," she said.

"I had wine last night at an Italian bistro," I confessed.

Sometimes you've just got to stare down the risk and go on living. One cocktail hour at a time.

Bowlcut
23-04-2008, 09:29 AM
Looks like the main point is that excessive drinking causes a risk for breast cancer. I can't say I am no surprised because we all know booze in men elevates levels of estrogen and there seems to be a well known link between high levels of estrogen and certain forms of cancer.
Gotta live life though

Gettin'r'round
23-04-2008, 10:26 AM
(HealthDay News) -- Alcohol, consumed even in small amounts, increases the risk of breast cancer and particularly estrogen-receptor and progesterone-receptor positive breast cancer, a new study shows.

The findings, expected to be presented Sunday at the annual meeting of the American Association for Cancer Research, in San Diego, are followed by a second study that found an association between breast cancer risk and two genes involved in alcohol metabolism.

Previous data has suggested that consuming alcohol ups the risk of breast cancer, although the precise mechanisms have not been clarified.

In some forms of breast cancer, malignant cells have receptors that render them sensitive to hormones such as estrogen. The first study aimed to see if the hormone receptor status of the tumor influenced the relationship between alcohol consumption and breast cancer risk.

In the study, a team led by Dr. Jasmine Lew of the U.S. National Cancer Institute followed more than 184,000 postmenopausal women for an average of seven years.

Those who had less than one drink a day had a 7 percent increased risk of breast cancer compared to teetotalers, the team reported. Women who drank one to two drinks a day had a 32 percent increased risk, and those who had three or more glasses of alcohol a day had up to a 51 percent increased risk.

But the risk was seen mostly in those 70 percent of tumors classified as estrogen receptor- and progesterone receptor-positive. Researchers suspect that alcohol may have an effect on breast cancer via an effect on estrogen.

The risk was similar whether women consumed primarily beer, wine or spirits, the NCI team noted.

The second study dug deeper into other possible mechanism by which alcohol consumption increases breast cancer risk.

"For years, we've known that there's an association between alcohol drinking and breast cancer risk, but nobody knows yet what the underlying biological mechanisms are," said Dr. Catalin Marian, lead author of the study and a research instructor in oncology at the Lombardi Comprehensive Cancer Center at Georgetown University in Washington, D.C. "The logical step was to begin analyzing the alcohol metabolizing genes."

And indeed, two of these genes -- ADH1B and ADH1C -- were associated with a two-fold increase in breast cancer risk.

But the study does not prove a definite cause-and-effect link. "This is an association," Marian said. "This type of study is good for generating hypotheses. It's not a definite conclusion. It needs to be replicated by other studies to say for sure that what we found is there."

Another researcher urged caution in interpreting the results of both studies.

"These studies are too early for use in a clinical setting or to advance a public health message," said Dr. Peter Shields, co-author of the genetics study and deputy director of the Lombardi Comprehensive Cancer Center.

However, he added that the findings "really do advance science, and, with proper replication in other studies, then they may be highly clinically significant."

Felinecougar
23-04-2008, 02:22 PM
And yet more on it....

http://www.amsa.org/resource/natlinit/alcohol.cfm

I was just talking about the young women who go out on Friday and Sat nights drinking, and then take 8-9 Tylenols the next day to make it to work or be able to function with a hang over.
This danger is unknown to them and needs to be advertised and warnings posted in Ladies rooms where they are drinking at or on bar coasters.