JonnyO
06-10-2010, 01:21 PM
Interesting Supplement for 17aa users. I know I steer clear or orals lately, but after reading about this product, if I do decide to use orals I wouldnt without taking this supplement.
You have to understand how 17aa are metabolized in the system to understand how this would be valuable...
TAUROURSODEOXYCHOLIC ACID (TUDCA)
A commonly prescribed drug for cholestasis is called Ursodiol (UDCA). However, it is a prescription drug and therefore NOT an option for OTC use. Fortunately, we believe there is a better choice, and that is tauroursodeoxycholic acid (TUDCA). TUDCA is the taurine conjugate of UDCA. It is an endogenous bile acid (found in bear gall bladder) accounting for a small percent of the bile found in the human body and has been used for years to treat liver disorders.
TUDCA aids in normal liver function in many ways. First, this bile acid acts to restore bile acid transporters. Doing this allows bile to flow normally via these transporters. Not only that, but it also acts to prevent formation of the toxic steroid glucuronides in the first place. A 2003 study showed that TUDCA is a noncompetitive inhibitor of steroid glucuronidation in vivo and in vitro(3). This means fewer toxic metabolites will be made in the first place! And, TUDCA may also increase the excretion of any glucuronide metabolites that do get formed, so they will not be around long enough in the liver to start down regulating any bile acid transporters(4).
As you can see, TUDCA is targeted toward steroid toxicity, and is not your typical run of the mill liver protector made with milk thistle. TUDCA helps prevent the formation of toxic steroid metabolites, reverses the toxic actions of those metabolites that do get formed, and speeds the elimination of the metabolites from the liver.
It is important to note that ThermoLife does not advocate the use of steroids. But the reality is that many people do use these products and do so without medical supervision. If you are going to do it, do it right.
A product such as Liver Longer may be extremely valuable as a health protective measure to anyone who chooses to use oral steroids, whether they are legal dietary supplements or illegal anabolic steroids.
You have to understand how 17aa are metabolized in the system to understand how this would be valuable...
TAUROURSODEOXYCHOLIC ACID (TUDCA)
A commonly prescribed drug for cholestasis is called Ursodiol (UDCA). However, it is a prescription drug and therefore NOT an option for OTC use. Fortunately, we believe there is a better choice, and that is tauroursodeoxycholic acid (TUDCA). TUDCA is the taurine conjugate of UDCA. It is an endogenous bile acid (found in bear gall bladder) accounting for a small percent of the bile found in the human body and has been used for years to treat liver disorders.
TUDCA aids in normal liver function in many ways. First, this bile acid acts to restore bile acid transporters. Doing this allows bile to flow normally via these transporters. Not only that, but it also acts to prevent formation of the toxic steroid glucuronides in the first place. A 2003 study showed that TUDCA is a noncompetitive inhibitor of steroid glucuronidation in vivo and in vitro(3). This means fewer toxic metabolites will be made in the first place! And, TUDCA may also increase the excretion of any glucuronide metabolites that do get formed, so they will not be around long enough in the liver to start down regulating any bile acid transporters(4).
As you can see, TUDCA is targeted toward steroid toxicity, and is not your typical run of the mill liver protector made with milk thistle. TUDCA helps prevent the formation of toxic steroid metabolites, reverses the toxic actions of those metabolites that do get formed, and speeds the elimination of the metabolites from the liver.
It is important to note that ThermoLife does not advocate the use of steroids. But the reality is that many people do use these products and do so without medical supervision. If you are going to do it, do it right.
A product such as Liver Longer may be extremely valuable as a health protective measure to anyone who chooses to use oral steroids, whether they are legal dietary supplements or illegal anabolic steroids.