Methyltrienolone.......?

[OntariOMuscle101]

I posted this same thing at 2 other board I frequently visit and only 4 ppl gave their 2 cents but straight to the point......

Has anybody had experience with this compound? I have been researching for a long time, and i think in the distant future I would like to try it for 3 weeks @ 500mcg-750mcg @ the begining 3 weeks then last 3 weeks with 500mg/Prop for 9 weeks. I have read that the fat burning properties are nothing short of amazing. Chimme in if you have knowledge on this compound.

thanks...

OM101

[GYMBRAT]

sorry no knowledge on it, but sounds very interesting and hope you get a few more posts on this subject bro

....I did read some interesting info on it over at steroid.com

[GYMBRAT]

not sure if you've read it but here you go man,

Methyltrienolone
Methyltrienolone (MT) is a very potent, reasonably toxic, non-aromatizing steroid. Ok. Let´s go over those three points again. First of all, MT is potent. It binds so strongly to the AR (androgen receptor) that it is often used in studies on other androgens to measure how strongly they bind. In other words, this stuff binds onto the AR receptor so strongly that it is pretty much the benchmark for that quality. If you´ve read my profile on Trenbolone Acetate (TA), you´ll note that I said TA is the most potent injectable weapon in our arsenal with regards to ability to bind to the Androgen receptor. That´s still true, because this particular compound is not in our arsenal, and it´s not injectable... it´s simply the oral version of TA (i.e. it is Trenbolone which has undergone modification to become orally active, via the addition of a 17-alph-methyl group). So why is it important that this stuff binds so tightly to the AR? Well, Androgen Receptors are found in both fat cells as well as muscle cells(8); they act on the AR in muscle cells to promote growth, and in the fat cells to affect fat burning.(9)(6) The stronger the androgen binds to the A.R, the higher the lipolytic (fat burning) effect on adipose (fat)tissue(9)(5). Unfortunately, that strong binding doesn´t also automatically mean that it will elicit the strongest possible anabolic response, nor that the weakest bind will elicit a weak anabolic response. Anadrol (oxymetholone) has the weakest bind to the AR possible (too low to be measured), and it produces a profound anabolic response, for example. Dianabol is simarly low, and produces a very good anabolic response. AR´s are found in both muscle tissue as well as adipose tissue. When a muscle´s AR is stimulated, it can induce hypertrophy. When an adipose tissue´s AR is stimulated, through various related mechanisms, fat is lost. This is a gross oversimplification. Whatever. All we need to know is that when you have a steroid that binds to the AR, it builds muscle and burns fat. And a steroid that binds very tightly to the AR will stimulate a lot of muscle synthesis and burn a lot of fat. A good example of this is Trenbolone. And since I mentioned Trenbolone, its worth further mentioning that MT is basically a 17aa (oral) version of (injectable) Trenbolone. AR binding and AR stimulation is not the only mechanism which stimulates anabolism, however. It is important to note that dbol has a very low AR binding ability and A50 has an AR binding ability which is too low to even measure! Both are very potent oral steroids, though. So while it´s important, AR binding/stimulation is not the end all & be all of anabolism, although it is an important part. Don´t be fooled by the anabolic/androgenic ratio of this (or any steroid), either. The anabolic/androgenic ratio of MT would suggest that it produces 120(+)x the anabolic and 60(+)x androgenic effect of Testosterone (which has a score of 100 and 100 respectively). If one were able to get a bottle of this stuff, I believe it would be best used as part of a cutting cycle, stacked with some injectables (testosterone, etc... ), but certainly no other orals. It´s just too toxic. Negma (the French company who brought Parabolan to the market, and then discontinued it) never pushed MT to gain approval as a commercially released item, since their original studies showed it to be highly toxic. Methyltrienolone is, of course, a 19Nor compound (as is Trenbolone)...Thus, it will effect your sexual drive and performance in a similar way to both Tren and Nandrolone, meaning that Temporary Impotence and/or a lack of libido is highly possible (aka Tren-Dick or Deca Dick)(10). Another problem with MT is that it is a progestin, and binds shockingly well to the progesterone receptor also (PgR) (3). As we know, progestins amplify estrogenic effects of Aromatizing drugs. Although MT doesn´t aromatize, you will still need to worry about its ability to cause side-effects by amplifying the estrogenic issues caused by the other compounds you may be taking. How toxic is this stuff? Well, it was never commercially marketed for use in humans, and has been relegated to Steroid-Purgatory, to be used only in studies. I´d probably rate it on around the same level as taking very high doses of halotestin or methyltestosterone. And I´d probably recommend that people keep doses of this product very low, much lower than recommended doses typical of the other 2 compounds I just mentioned (i.e. 500-750mcgs/day, for not much longer than 3-4 weeks). I have had the good fortune to discuss this product with the owner of an Underground Lab, and he had given out several samples of this stuff to athletes he knew, and they all kept records and got regular bloodwork done. People who were in the 2mg/day range developed highly elevated liver enzymes and Jaundice (yellowing of the eyes and skin). They all recovered, and through trial and error, a 500-750mcg dose was found to be (*relatively) safe, and (*roughly) as effective as 150-225mgs of Trenbolone Acetate. For women, a possible side effect of MT is Virilization (development of male sexual characteristics), which is profound with this stuff (11), so it is entirely off limits for women to use. You may want to take milk thistle with this compound, should you decide to try it, as well as (320mgs/day), ALA (500mgs per meal) and try some Pygeum Africanum (Permixon, the liposterolic extract of Serenoa)... stuff will all protect either your prostate or liver... in one study, it inhibited competitively the binding of Methyltrienolone to the cytosolic receptor of the rat prostate. You´ll still need to get blood work done, avoid other orals (this includes drinking, or anything else which could tax your liver), and monitor your health closely. This isn´t a drug for novices, clearly, and is probably only useful for pre-contest bodybuilders. I´ve only seen MT available from one Underground Lab, and it came in a 50ml bottle, which was 1mg/ml, and was priced at $100. This translates to roughly 100 doses, at a reasonable cost of fifty-cents per dose. And since you would never want to run this particular drug for longer than 3-4 weeks at a time (maybe it would have use in the last few weeks before a bodybuilding competition, but not much else), you´ll get to use one bottle in 4 different cycles. That makes it no less dangerous, just reasonably cheap.
Methyltrienolone Profile

[17beta-Hydroxy-17-methylestra-4,9,11-trien-3-one]
Molecular Weight: 284.3974
Formula: C19H24O2
Melting Point: N/A
Manufacturer: Negma (never released), Underground Labs
Effective dose: 500-750mcgs/day
Active Life: 4-6hours
Detection Time: Unknown (never tested in humans)
Anabolic/Androgenic Ratio (estimated):12,000+/6,000+

References:



1. Endocrinology. 1984 Jun;114(6):2100-6.Relative binding affinity of anabolic-androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex hormone-binding globulin.
2. Bonne C, Raynaud JP. Methyltrienolone, a specific ligand for cellular androgen receptors. Steroids 1975 Aug;26(2):227-32
3. Dube JY, Tremblay RR, Chapdelaine P. Binding of methyltrienolone to various androgen-dependent and androgen-responsive tissues in four animal species. Horm Res 1976;7(6):333-40
4. Tremblay RR, Dube JY, Ho-Kim MA, Lesage R. Determination of rat muscles androgen-receptor complexes with methyltrienolone. Steroids 1977 Feb;29(2):185-95 5. APMIS. 2000 Dec;108(12):838-46.
5. APMIS. 2000 Dec;108(12):838-46.
6. (Xu X, et al. "The effects of androgens on the regulation of lipolysis in adipose precursor cells." Endocrinology 1990 Feb;126(2):1229 ).
7. J Anim Sci. 1992 Nov;70(11):3381-90.
8. Am J Physiol. 1998 Jun;274(6 Pt 1):C1645-52.
9. Biochim Biophys Acta. 1995 May 11;1244(1):117-20.
10. Baum MJ, Kingsbury PA, Erskine MS. Failure of the synthetic androgen 17 beta-hydroxy-17 alpha-methyl-estra-4,9,11-triene-3-one (methyltrienolone, R1881) to duplicate the activational effect of testosterone on mating in castrated male rats. J Endocrinol 1987 Apr;113(1):15-20
11. Biochem Pharmacol. 1984 Apr 15;33(8):1235-41.Changes in the activities of microsomal enzymes involved in hepatic steroid metabolism in the rat after administration of androgenic, estrogenic, progestational, anabolic and catatoxic steroids.

[natenator]

*sigh* so steroids burn fat huh?

[GYMBRAT]

yeah fairly obvious but

[cog]

Why **** with these Russian roulette orals when you can get Tren a easily?

[Kilburn]

*sigh* so steroids burn fat huh?

youre saying tren deosnt help you cut down? are you stupid?

as for MT, fuk that OP. why are you putting yourself at risk with that sht? for me the sides on tren are unbarable as it is. but whatever, if you think it's so cool then go for it i guess.

[natenator]

youre saying tren deosnt help you cut down? are you stupid?

as for MT, fuk that OP. why are you putting yourself at risk with that sht? for me the sides on tren are unbarable as it is. but whatever, if you think it's so cool then go for it i guess.
Are you saying tren will directly oxidize adipose????

[btufts]

steroids do not burn fat, the cardio and diet you do on them will burn fat... sigh. tren is more so a hardener than anything so when you think you're losing fat it's just an illusion

[btufts]

that's like saying if i took steroids and ate what i want i'll get ripped... oh my

[Rrrrolla]

Steroids might not DIRECTLY burn fat, but they certainly do make it harder for your body to burn muscle. They do indirectly make you burn MORE fat if youre dieting. And if youre bulking, the ratio of muscle to fat gain is going to favor muscle more than if you were clean. Soooo... ya. Thats how I look at it. To someone that doesnt understand this, its probably easier to tell them that they burn fat and make more muscles.

[natenator]

Steroids might not DIRECTLY burn fat, but they certainly do make it harder for your body to burn muscle. They do indirectly make you burn MORE fat if youre dieting. And if youre bulking, the ratio of muscle to fat gain is going to favor muscle more than if you were clean. Soooo... ya. Thats how I look at it. To someone that doesnt understand this, its probably easier to tell them that they burn fat and make more muscles.
right, they create the conditions for it. They don't specifically oxidize it.

[Rrrrolla]

Its easy to see how people could think they burn fat though, especially androgens. With anabolics you hold a bunch of water that looks alot like fat, so even though your body might be actually reducing its fat relative to muscle, you dont really see it as much. But with androgens like tren, you dont hold water, so as your ratio of muscle to fat increases, the change is more noticeable. To explain that you arent burning fat, youre just gaining muscle because more of your calories are being used to build muscle and less are being used to build fat, might be too complicated for some to understand. Besides, any novice that just takes tren and doesnt eat, is going to wind up losing some fat and gaining some muscle when all is said and done. Then he'll go right back to where he started. It probably looks like a miracle drug to him. It probably also made him the toughest guy in the bar LOL!

[clicker666]

It's really easy to see how people think it burns fat when the actual profile SAYS it burns fat. That's probably why people are confused. It says right there that there is a strong AR affinity which causes muscle development and fat burning.

Given that most newbies have little to work with, it's not hard to see why they would read the profile and come to the conclusion that methyltren is effective as a fat burner.

[OntariOMuscle101]

This compound is some serious shit, I may not do it until I can research more on it. But anything that mimics Trenbolone, Stanozolol and Primobolan has to do some serious thinggs that are amazing for gains/fat but def has very harsh side effects.......still would like to hear peoples opinions on this if there are any fellow canucks that can chimme in...

[L3]

im sure some of you have seen the aftermath of near liver faliure... looks something like tihs:

http://2.bp.blogspot.com/_rG2dquD5xoo/S4ivCVwmRzI/AAAAAAAAARQ/JO8uRXXfR2w/s400/rosacea_001.JPG

a guy i know ended up in the hospital after 3 weeks on abombs and almost died, now his face is a perma tomatoe

enjoy the methyl tren

[PdH]

^^^^Fully agreed. I'm not sure why anyone would **** around with this stuff. Seems to be about on par with Check Drops for toxicity.

[GYMBRAT]

yup I'm happy with what I know and trust ;)

[Anadrolaholic]

I posted this same thing at 2 other board I frequently visit and only 4 ppl gave their 2 cents but straight to the point......

Has anybody had experience with this compound? I have been researching for a long time, and i think in the distant future I would like to try it for 3 weeks @ 500mcg-750mcg @ the begining 3 weeks then last 3 weeks with 500mg/Prop for 9 weeks. I have read that the fat burning properties are nothing short of amazing. Chimme in if you have knowledge on this compound.

thanks...

OM101
I'm Currently running 200mg eod of primo inject, and 150mg of test prop. Both Canadian UGL's. I'm noticing a lot of lean muscle mass going into week 4 now. I've only put on about 10 pounds, but very little of that is water retention. The pumps are sick and do not let up all evening into the next day. I'm peppering in some masteron starting week 6 and going to the end of week 14. No sides, 2 big zits, some extra grease but nothing to complain about. Hope this helps

[1488]

^^ Skin and eyes going YELLOW is a sign of near liver failure. That red face with the busted capillaries is commonly the sign of a chronic heavy drinker, or someone with a medical condition called extreme rosacea, caused by a number of possible things.