when do receptors start to down grade in cycle?

[musclehead123]

Okay I'm trying to figure out when receptors start to down grade in a cycle. For example if one was to do a test E cycle would receptors start to down grade as soon as the test got into the blood stream. Or would they start to down grade in week 4?

Reason I am asking is it better to kickstart a cycle with test P until week 4 or should one just wait for the test E to kick in?

[nitrous]

they wouldnt down grade right when it kicks in.. they do this because they get use to a huge flush of test... whether this is test prop or test e it doenst matter it will take the same time i would think... using test p you would simply have it happen sooner since it kicks in sooner.. also how long it takes i would say that is dosage dependent and person dependent because everyone is different

[natenator]

I'd like to see a study showing me that receptors downgrade...

[musclehead123]

I'd like to see a study showing me that receptors downgrade...


okay maybe downgrade was the wrong word, but people build tolerances to drugs. For example, if i do X amount of one drug and it has a Y effect on me. The next time i do that same drug and use X amount it might have Y-1 effect on me. So I have to increase the dosages to get Y effect again because now i would be losing some of the drug to antibodies.

So I guess the question is would a person's tolerance levels increase if they were to kickstart with Test P on a test E cycle, or would they stay the same if they were to just do test E?

[Redz]

This is an interesting topic, I would like to see some actual studies and facts on this.

[Kronis]

I'd like to see a study showing me that receptors downgrade...

My addictions textbook has studies saying steroids upgrade androgen receptors.

They work less because you now weigh more and are larger than your body probably wants to be.

There's a nice thread over on AF about why gains slow after 8 weeks, it's worth checking out.

Here's the main post:

So as has been posted a million times it's widely accepted that your cycle will stall in week 8. Search those words and I bet I've posted them 1000 time myself.
What we didn't know was why. Now we know why, or at least how your body does this dastardly deed. You guys remember the study done in 2005 by Shalender Bhasina? The one where they gave men 75-600mg/wk of Test? "Testosterone dose-response relationships in healthy young men" Well the author published a new study that was released a couple months ago.

Measurement of myostatin concentrations in human serum:
Circulating concentrations in young and older men and effects
of testosterone administration (http://www.afboard.com/library/Measurement%20of%20myostatin%20concentrations%20in %20human%20serum%20Circulating%20concentrations%20 in%20young%20and%20older%20men%20and%20effects%20o f%20testosterone%20administration.pdf).

Contrary to what they were expecting to see, it seems that by day 56 myostatin levels were much higher. So in week 8 it was causing LBM gains to stall, you know, like we know they do. But here's the good news. By the end of the study in week 20 they were back to baseline.

The moral of the story is to do 8 week cycles or stay on. :)

[GYMBRAT]

I'd like to see a study showing me that receptors downgrade...

x2, this is something I don't believe in from my own experience on long and or short cycles...

[Chaps]

Injectable L-carninite or oral L-carnitie L-tartrate will upgregulate the androgen receptors, read about it on professionalmuscle.com interesting stuff, looks like the injectable l-carnitine is the way to go and it looks like you can get it cheap from a vet supplier.

[Retics]

Yea I dont know a whole lot about receptors , A buddy of mine gave me a sched to fallow but not sure this is right for me,, lil too hard core,, "He" says that this will give you better gains cause you are changing doses,, I have stuck with the same dose for 12 weeks then started with my pct after,, any info on this?

TNT 400 / DECA 300/ SUST 250/ 9 WEEK STACK

WEEK 1. TNT-400 / 0.5ml
DECA-300/ 0.5ml
SUSTANON-250/ 0.5ml
OXYMETHALONE (ANIDROL) one 25 mg tab daily.

WEEK 2. TNT-400/ 0.75ml
DECA-300/ 0.75ml
SUSTANON-250/ 0.75ml
OXYMETHALONE (ANIDROL) two, 25 mg tabs daily.

WEEK 3. TNT-400 / 1.0ml
DECA-300 / 1.0ml
SUSTANON-250/ 1.0ml
OXYMETHALONE (ANIDROL) three , 25 mg tabs daily.

WEEK 4. TNT-400 / 1.0ml
DECA-300 / 1.25ml
SUSTANON-250/ 1.0ml
OXYMETHALONE (ANIDROL) three , 25 mg tabs daily.

WEEK 5. OFF!!!!! NO GEAR!! 50 mg NOLVADEX DAILY.
50 mg CLOMEPHENE DAILY.
0.04 mg CLENBUTEROL DAILY.

WEEK 6. OFF!!!!! NO GEAR!! 50 mg NOLVADEX DAILY.
50 mg CLOMEPHENE DAILY.
0.04 mg CLENBUTEROL DAILY.

WEEK 7. TNT-400/ 1.0ml
SUSTANON-250/ 1ml
DECA-300/ 1.25ml
OXYMETHALONE (ANIDROL) three , 25mg tabs daily.

WEEK 8. TNT-400/ 0.75 ml.
DECA-300/ 1.0 ml.
SUSTANON-250 0.75 ml.
OXYMETHALONE (ANIDROL) two , 25 mg tabs daily.

WEEK 9. TNT-400/ 0.5 ml.
SUSTANON-250/ 0.5 ml.
DECA-300 0.75 ml.
OXYMETHALONE (ANIDROL) one 25 mg tab daily.


WEEKS 10-11. 50 mg of NOLVADEX DAILY.

WEEKS 12-13. 25 mg of NOLVADEX DAILY.

[tex]

they dont.