sublingual peptides (hexarelin)

[MMASTAR]

I have been doing reshearch on peptides lately and decided i want to use hexarelin, as i am dieting and do not need the added hunger of using ghrp-2or6, however i am not a fan of injecting 3 times a day and dont want to inject at work. I have read that the efficacy of peptides are only slightly diminished when used subligualy. I have never home brewed and am not to sure about how this would work. Is bacteriostatic water drinkable? Or would i just reconstitute it with purified water so it would be acceptable for consumption? I would be wanting to use hexarelin at 250 mcg a day. (opinions on this dose please) It comes in 2mg vials. So, correct me if im wrong, if i add 8mls of water that would make my solution 250mcg's per ml?? so 1/3ml 3 times a day=250mcg's a day? Also canadian med supplies does not sell this peptide so i would source it elsewhere. I have found it but there is always the disclaimer that it is for reshearch only not to be consumed, injected ect. This is just a disclaimer right? it has a purity of 98%, any thoughts on any of this would be appreciated. Thanks.

[theboss]

i have been told its useless.

[MMASTAR]

Abstract
After repeated intravenous (i.v.) boluses of growth hormone-releasing peptide-6 (GHRP-6) we found recently increases of growth hormone (GH), corticotropin (ACTH) and cortisol levels and of the amount of stage 2 sleep, In clinical use, oral (p.o.), intranasal (i.n.) and sublingual (s.l.) routes of administration have advantages over i.v. administration, We compared the sleep-endocrine effects of 300 mu g/kg of body weight (b.w.) GHRP-6 in enteric-coated capsules given p.o. at 21.00 h and of 30 mu g/kg GHRP-6 i.n. or 30 mu g/kg GHRP-6 st. given at 22.45 h in normal young male controls with placebo conditions. After GHRP-6 p.o. secretion of GH, ACTH and cortisol remained unchanged. The only effect of GHRP-6 s.l. was a trend toward an increase in GH in the first half of the night. GHRP-6 i.n. prompted a significant increase in GH concentration during the total night and a trend toward an increase in ACTH secretion during the first half of the night, whereas cortisol secretion remained unchanged. Furthermore, after GHRP-6 i.n., sleep stage 2 increased in the second half of the night by trend, and spectral analysis of total night non-rapid eye movement (REM) sleep revealed a decrease of delta power by trend. In contrast sleep stage 2 decreased during the second half of the night after GHRP-6 p.o. Our data demonstrate that GHRP-6 is capable of modulating GH and ACTH secretion as well as sleep. However, the effects depend upon dosage, duration and route of administration. [References: 41]


After repeated intravenous (i.v.) boluses of growth hormone-releasing peptide-6 (GHRP-6) we found recently increases of growth hormone (GH), corticotropin (ACTH) and cortisol levels and of the amount of stage 2 sleep, In clinical use, oral (p.o.), intranasal (i.n.) and sublingual (s.l.) routes of administration have advantages over i.v. administration, We compared the sleep-endocrine effects of 300 mu g/kg of body weight (b.w.) GHRP-6 in enteric-coated capsules given p.o. at 21.00 h and of 30 mu g/kg GHRP-6 i.n. or 30 mu g/kg GHRP-6 st. given at 22.45 h in normal young male controls with placebo conditions. After GHRP-6 p.o. secretion of GH, ACTH and cortisol remained unchanged. The only effect of GHRP-6 s.l. was a trend toward an increase in GH in the first half of the night. GHRP-6 i.n. prompted a significant increase in GH concentration during the total night and a trend toward an increase in ACTH secretion during the first half of the night, whereas cortisol secretion remained unchanged. Furthermore, after GHRP-6 i.n., sleep stage 2 increased in the second half of the night by trend, and spectral analysis of total night non-rapid eye movement (REM) sleep revealed a decrease of delta power by trend. In contrast sleep stage 2 decreased during the second half of the night after GHRP-6 p.o. Our data demonstrate that GHRP-6 is capable of modulating GH and ACTH secretion as well as sleep. However, the effects depend upon dosage, duration and route of administration. [References: 41]
-------------------------------------------------------------------------------

The secretion of growth hormone (GH) from the pituitary gland is regulated by the central nervous system. At the hypothalamic level, two peptides, growth hormone releasing hormone (GHRH) and somatostatin modulate the secretion of GH. GHRH stimulates GH secretion while somatostatin exhibits an inhibitory influence.

Other peptides of different size and structure are able to influence GH secretion in man and several other animal species. Amongst these, a synthetic hexapeptide (GHRP-6), derived from an enkeph**** analogue, specifically stimulates GH release both after parenteral and oral administration. The oral activity of GHRP-6 has opened up new perspectives in the treatment of several conditions associated to hypothalamic growth hormone deficiency. It has also prompted the development of new synthetic peptides, possessing greater potency, a longer duration of action and an increased oral bioavailability.

Hexarelin (INN:Examorelin, MF 6003, EP 23905) is a new synthetic peptide formed by 6 aminoacids. Its chemical structure is His-DTrp(2-Me)-Ala-Trp-DPhe-Lys-NH2. Compared to GHRP-6, hexarelin is more resistant to proteolytic degradation.

An extensive package of toxicological studies has been performed. No organ specific toxicity was observed. No toxic effects were recorded on the cardiovascular system, renal function and CNS. Pharmacokinetic studies are available in rats and dogs. The drug is absorbed by the subcutaneous and oral routes. The half-life of hexarelin is 2 hours in dogs after bolus iv administration.

Hexarelin stimulates GH secretion following intravenous, subcutaneous, intranasal and oral administration. In man, a bolus intravenous dose of 1 mg/kg induces peak plasma GH concentrations of around 70 ng/mL within 15 minutes. The mechanism of action of hexarelin has still not been fully elucidated. The peptide seems to act on pituitary binding-sites and to modulate intracellular messenger pathways different from those associated with GHRH. Its low toxicity, marked and specific stimulation of GH secretion along with its rapid absorption after oral administration, strongly indicate that it could be employed as a diagnostic and therapeutic tool in GH secretory disorders.

High-affinity binding sites for hexarelin have been identified in human cardiac and vascular tissues. Various animal models have evidenced a strong protective effect of hexarelin in post-ischemic ventricular dysfunction. Hexarelin improves cardiac function in rats with experimentally induced congestive heart failure. These cardiovascular effects have also been observed in hypophysectomized animals and occur at doses far lower than those required to elicit GH secretion.

Hexarelin has been administered to about 1,000 subjects. Phase 1 studies have shown that the drug is well tolerated after i.v. administration of doses up to 2 mg/kg. Chronic intranasal administration of hexarelin has been shown to accelerate growth in short children. Endocrine effects have been demonstrated after chronic oral administration in elderly subjects.

[theboss]

i have been told its useless for bodybuilding.

[MMASTAR]

im not expecting to get huge of it... just some strentgh, some fat loss and and some lean muscle... kindof an expirement... would be a good thing to log for others.. just wondering if any1 has any input and if my math sounds right...

[theboss]

basically i was told not to waste money on it....save up for HGH.

[cog]

MMASTAR,try this calculator.

http://www.onlineconversion.com/weight_all.htm