Testosterone Sublingual Spray

[Memo]

This is a product from a Canadian chem supplier. They say it will be absorbed subliminally at 80%.

I am curious, how much of this actual testosterone will be going to the bloodstream, and is it some kind of test sus, with no ester?

Thanx for the info.

They also have Trenbolone Acetate.. It sound to me like a very easy way to over-under dose everyday and have a roller coaster cycle.

[Seth]

edited: nm, I checked your posts and since you've already got yourself 2 cycles under your belt my post was useless

[toynut]

I would be curious about this also,
I am aware of spray's but not really time delay (ester for injects)
when to use (ed/eod/e3d) and how to work out PCT?

[hyperlite32]

I am sure somone here has info about sub sprays... The sub sprays are very interesting.

[O-Train]

The beauty of sublingual administration is that it is absorbed into the blood stream. You probably won't get the same absorption compared with IM, IV or SC but it is a lot better than PO (oral). It avoids the first pass effect by the liver.

Should be fine as long as the product is what it claims to be, just don't swallow it.

[toynut]

Hurley, i agree with you but how long does it stay in your system?

12hrs like suspension? 2 weeks like cyp?

[O-Train]

Hurley, i agree with you but how long does it stay in your system?

12hrs like suspension? 2 weeks like cyp?

No clue. No experience with this. You're talking Pharmacokinetics. Once in the blood stream route of administration doesn't matter. Although if sublingual absorption is slightly lower than IM than you would need a larger dose to get the same quantity of drug into circulation.

I'm confident all of this information is available on the internet. Did a quick search and found this: (it may be different than the original posters question because he just said testosterone, he didn't specify)

Pharmacokinetics, bioefficacy, and safety of sublingual testosterone cyclodextrin in hypogonadal men: comparison to testosterone enanthate-- a clinical research center study
B Salehian, C Wang, G Alexander, T Davidson, V McDonald, N Berman, RE Dudley, F Ziel and RS Swerdloff
Department of Medicine, Harbor-UCLA Medical Center, Torrance 90509, USA.

We studied and compared the pharmacokinetics and bioefficacy of two doses of sublingual testosterone cyclodextrin (SLT; 2.5 and 5.0 mg, administered three times per day) with testosterone enanthate (TE; 200 mg) given once every 20 days by im injections over a 60-day study period in 63 hypogonadal men. After SLT administration, serum testosterone (T) levels peaked at 20 min and then fell, reaching baseline levels by 360 min. The calculated half-lives were 60.3 +/- 7.5 and 68.8 +/- 5.0 min after a single dose of 2.5 and 5.0 mg SLT, respectively. The mean area under curve (AUC) of serum T was computed over 20-day periods for the 3 treatment groups. The mean net AUC of serum T after TE administration was about 4- and 2-fold higher than that in the 2.5 and 5 mg groups over the last 20 days. Serum estradiol and dihydrotestosterone followed the same pattern as serum T. Serum estradiol to T ratios decreased after T replacement in all 3 groups, whereas serum dihydrotestosterone to T ratios were not significantly changed by T treatment. Suppression of serum LH and FSH levels was more marked in the patients treated with TE than in those given SLT. Similarly, serum sex hormone-binding globulin levels showed significant decreases with androgen replacement only in the TE and SLT 5.0 mg range groups. There were no significant adverse effects based on comprehensive physical examinations, urea, electrolytes, and renal or liver function tests. Hematocrit levels increased in the TE-treated group, but remained slightly lower than baseline levels in the SLT groups. Serum high density lipoprotein cholesterol showed a small, but significant, decrease with time of treatment in all groups. Despite the differences in the AUC of serum T levels achieved by different androgen replacement therapies, all patients showed significant improvements in sexual motivation and performance, with no significant difference between the treatment groups. We conclude that SLT may be a useful addition to the currently available injectable and transdermal delivery systems for treatment of hypogonadal men. Because of the ease of administration, rapid reversibility of effects, and lower AUC of serum T levels achieved compared to those of TE injections, SLT may be especially suitable for treatment of boys with delayed puberty and older men with androgen deficiency.

[toynut]

Thanx Hurley,
What i get from this is that the peak comes quick and goes away even faster compared to injects,

:levels peaked at 20 min and then fell, reaching baseline levels by 360 min:

almost seems like twice to three times a day every day?

[cdnsoldier]

Thanx Hurley,
What i get from this is that the peak comes quick and goes away even faster compared to injects,

:levels peaked at 20 min and then fell, reaching baseline levels by 360 min:

almost seems like twice to three times a day every day?

It's made from test base.I am telling you this from personal expereince; Stick with Injects.

The results are impressive but the sides are too heavy. Don't think it's a test e. or c type sides. It's between M1 and test. c. Not as bad as m1, not as good as test. c.

And I suspect they are using DMSO and cylco since it has that sulphur taste. It's an ok product but not a replacement for injects.No where near .

PS. By 'personal experience' I mean I have tried this product from that company.

[O-Train]

Thanx Hurley,
What i get from this is that the peak comes quick and goes away even faster compared to injects,

:levels peaked at 20 min and then fell, reaching baseline levels by 360 min:

almost seems like twice to three times a day every day?

Assuming the drug is the same as the one mentioned in the study. Otherwise everything changes. With a t1/2 of 1hr...it isn't very practical. The study I read discussing test undecanoate injected IM. Then you're talking terminal t1/2 of ~22-30 days. That seems much more reasonable. Actually the same study listed a terminal half life for test e of 10.3 +/-1.1 days. Is this roughly the accepted value you guys go by?

I was wondering what terminal half life meant so I looked it up:

Terminal plasma half-life is the time required to divide the plasma concentration by two after reaching pseudo-equilibrium, and not the time required to eliminate half the administered dose. When the process of absorption is not a limiting factor, half-life is a hybrid parameter controlled by plasma clearance and extent of distribution. In contrast, when the process of absorption is a limiting factor, the terminal half-life reflects rate and extent of absorption and not the elimination process (flip-flop pharmacokinetics). The terminal half-life is especially relevant to multiple dosing regimens, because it controls the degree of drug accumulation, concentration fluctuations and the time taken to reach equilibrium.

[Memo]

edited: nm, I checked your posts and since you've already got yourself 2 cycles under your belt my post was useless

I am very confuse, how did you come to this conclusion. I actually never used aas yet, Just got my vials for a cycle i start next month.

EDIT: I understand now, I was quoting someone in the message saying 18 and 2 cycle already.

Sorry about confusion.